Abstract
Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown. Here, we present a unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, revealing tissue-intrinsic compartmentalization of naive, effector, and memory subsets conserved between diverse individuals. Effector memory CD4+ T cells producing IL-2 predominated in mucosal tissues and accumulated as central memory subsets in lymphoid tissue, whereas CD8+ T cells were maintained as naive subsets in lymphoid tissues and IFN-γ-producing effector memory CD8+ T cells in mucosal sites. The T cell activation marker CD69 was constitutively expressed by memory T cells in all tissues, distinguishing them from circulating subsets, with mucosal memory T cells exhibiting additional distinct phenotypic and functional properties. Our results provide an assessment of human T cell compartmentalization as a new baseline for understanding human adaptive immunity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 187-197 |
| Number of pages | 11 |
| Journal | Immunity |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 24 2013 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
- Immunology
Cite this
Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets. / Sathaliyawala, Taheri; Kubota, Masaru; Yudanin, Naomi; Turner, Damian; Camp, Philip; Thome, Joseph J C; Bickham, Kara L.; Lerner, Harvey; Goldstein, Michael; Sykes, Megan; Kato, Tomoaki; Farber, Donna L.
In: Immunity, Vol. 38, No. 1, 24.01.2013, p. 187-197.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets
AU - Sathaliyawala, Taheri
AU - Kubota, Masaru
AU - Yudanin, Naomi
AU - Turner, Damian
AU - Camp, Philip
AU - Thome, Joseph J C
AU - Bickham, Kara L.
AU - Lerner, Harvey
AU - Goldstein, Michael
AU - Sykes, Megan
AU - Kato, Tomoaki
AU - Farber, Donna L.
PY - 2013/1/24
Y1 - 2013/1/24
N2 - Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown. Here, we present a unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, revealing tissue-intrinsic compartmentalization of naive, effector, and memory subsets conserved between diverse individuals. Effector memory CD4+ T cells producing IL-2 predominated in mucosal tissues and accumulated as central memory subsets in lymphoid tissue, whereas CD8+ T cells were maintained as naive subsets in lymphoid tissues and IFN-γ-producing effector memory CD8+ T cells in mucosal sites. The T cell activation marker CD69 was constitutively expressed by memory T cells in all tissues, distinguishing them from circulating subsets, with mucosal memory T cells exhibiting additional distinct phenotypic and functional properties. Our results provide an assessment of human T cell compartmentalization as a new baseline for understanding human adaptive immunity.
AB - Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown. Here, we present a unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, revealing tissue-intrinsic compartmentalization of naive, effector, and memory subsets conserved between diverse individuals. Effector memory CD4+ T cells producing IL-2 predominated in mucosal tissues and accumulated as central memory subsets in lymphoid tissue, whereas CD8+ T cells were maintained as naive subsets in lymphoid tissues and IFN-γ-producing effector memory CD8+ T cells in mucosal sites. The T cell activation marker CD69 was constitutively expressed by memory T cells in all tissues, distinguishing them from circulating subsets, with mucosal memory T cells exhibiting additional distinct phenotypic and functional properties. Our results provide an assessment of human T cell compartmentalization as a new baseline for understanding human adaptive immunity.
UR - http://www.scopus.com/inward/record.url?scp=84872772721&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872772721&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2012.09.020
DO - 10.1016/j.immuni.2012.09.020
M3 - Article
C2 - 23260195
AN - SCOPUS:84872772721
VL - 38
SP - 187
EP - 197
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 1
ER -