Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

Taheri Sathaliyawala, Masaru Kubota, Naomi Yudanin, Damian Turner, Philip Camp, Joseph J.C. Thome, Kara L. Bickham, Harvey Lerner, Michael Goldstein, Megan Sykes, Tomoaki Kato, Donna L. Farber

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391 Scopus citations

Abstract

Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown. Here, we present a unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, revealing tissue-intrinsic compartmentalization of naive, effector, and memory subsets conserved between diverse individuals. Effector memory CD4+ T cells producing IL-2 predominated in mucosal tissues and accumulated as central memory subsets in lymphoid tissue, whereas CD8+ T cells were maintained as naive subsets in lymphoid tissues and IFN-γ-producing effector memory CD8+ T cells in mucosal sites. The T cell activation marker CD69 was constitutively expressed by memory T cells in all tissues, distinguishing them from circulating subsets, with mucosal memory T cells exhibiting additional distinct phenotypic and functional properties. Our results provide an assessment of human T cell compartmentalization as a new baseline for understanding human adaptive immunity.

Original languageEnglish (US)
Pages (from-to)187-197
Number of pages11
JournalImmunity
Volume38
Issue number1
DOIs
StatePublished - Jan 24 2013

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J. J. C., Bickham, K. L., Lerner, H., Goldstein, M., Sykes, M., Kato, T., & Farber, D. L. (2013). Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets. Immunity, 38(1), 187-197. https://doi.org/10.1016/j.immuni.2012.09.020