Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets

Taheri Sathaliyawala, Masaru Kubota, Naomi Yudanin, Damian Turner, Philip Camp, Joseph J C Thome, Kara L. Bickham, Harvey Lerner, Michael Goldstein, Megan Sykes, Tomoaki Kato, Donna L. Farber

Research output: Contribution to journalArticle

366 Citations (Scopus)

Abstract

Knowledge of human T cells derives chiefly from studies of peripheral blood, whereas their distribution and function in tissues remains largely unknown. Here, we present a unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, revealing tissue-intrinsic compartmentalization of naive, effector, and memory subsets conserved between diverse individuals. Effector memory CD4+ T cells producing IL-2 predominated in mucosal tissues and accumulated as central memory subsets in lymphoid tissue, whereas CD8+ T cells were maintained as naive subsets in lymphoid tissues and IFN-γ-producing effector memory CD8+ T cells in mucosal sites. The T cell activation marker CD69 was constitutively expressed by memory T cells in all tissues, distinguishing them from circulating subsets, with mucosal memory T cells exhibiting additional distinct phenotypic and functional properties. Our results provide an assessment of human T cell compartmentalization as a new baseline for understanding human adaptive immunity.

Original languageEnglish (US)
Pages (from-to)187-197
Number of pages11
JournalImmunity
Volume38
Issue number1
DOIs
StatePublished - Jan 24 2013
Externally publishedYes

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T-Lymphocyte Subsets
T-Lymphocytes
Lymphoid Tissue
Mucous Membrane
Adaptive Immunity
Interleukin-2
Tissue Donors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Sathaliyawala, T., Kubota, M., Yudanin, N., Turner, D., Camp, P., Thome, J. J. C., ... Farber, D. L. (2013). Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets. Immunity, 38(1), 187-197. https://doi.org/10.1016/j.immuni.2012.09.020

Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets. / Sathaliyawala, Taheri; Kubota, Masaru; Yudanin, Naomi; Turner, Damian; Camp, Philip; Thome, Joseph J C; Bickham, Kara L.; Lerner, Harvey; Goldstein, Michael; Sykes, Megan; Kato, Tomoaki; Farber, Donna L.

In: Immunity, Vol. 38, No. 1, 24.01.2013, p. 187-197.

Research output: Contribution to journalArticle

Sathaliyawala, T, Kubota, M, Yudanin, N, Turner, D, Camp, P, Thome, JJC, Bickham, KL, Lerner, H, Goldstein, M, Sykes, M, Kato, T & Farber, DL 2013, 'Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets', Immunity, vol. 38, no. 1, pp. 187-197. https://doi.org/10.1016/j.immuni.2012.09.020
Sathaliyawala T, Kubota M, Yudanin N, Turner D, Camp P, Thome JJC et al. Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets. Immunity. 2013 Jan 24;38(1):187-197. https://doi.org/10.1016/j.immuni.2012.09.020
Sathaliyawala, Taheri ; Kubota, Masaru ; Yudanin, Naomi ; Turner, Damian ; Camp, Philip ; Thome, Joseph J C ; Bickham, Kara L. ; Lerner, Harvey ; Goldstein, Michael ; Sykes, Megan ; Kato, Tomoaki ; Farber, Donna L. / Distribution and Compartmentalization of Human Circulating and Tissue-Resident Memory T Cell Subsets. In: Immunity. 2013 ; Vol. 38, No. 1. pp. 187-197.
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