Distortion product emissions in normal-hearing and low-frequency hearing loss carriers of genes for Waardenburg's syndrome

Xue Z Liu, England Harwell, Valerie E. Newton

Research output: Contribution to journalArticle

12 Scopus citations


Eight patients with Waardenburg's syndrome (WS) with normal heating and 3 additional patients exhibiting a low-frequency hearing loss were tested for the level of the acoustic distortion product 2f1-f2 by means of the Otodynamics Distortion Product Analyser (ILO92). Wide notches in distortion product otoacoustic emissions (DPOAEs) between 1,000 and 3,000 Hz were found in 7 (12 ears, 87.5%) examined patients with normal audiograms, which was a significantly higher rate than that found in the control group (10%). The 3 patients with low-frequency hearing loss gave a consistent pattern in audiometric configuration shown by both pure tone audiograms and DPOAEs. It is concluded from these initial results that DPOAEs may be a useful approach to identifying subclinical pathologic aberrations in the inner ear in WS patients, and may be a predictor of low-frequency sansorineural hearing loss.

Original languageEnglish
Pages (from-to)220-225
Number of pages6
JournalAnnals of Otology, Rhinology and Laryngology
Issue number3
StatePublished - Jan 1 1997
Externally publishedYes



  • distortion product otoacoustic emissions
  • low-frequency hearing loss
  • normal hearing
  • Waardenburg's syndrome

ASJC Scopus subject areas

  • Otorhinolaryngology

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