Distinctions between gap junctions and sites of intermediate filament attachment in the leech C.N.S.

David W. Pumplin, Kenneth J Muller

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Freeze-fracture studies on the nerve cord of the leech Hirudo medicinalis reveal that the plasma membranes of various cells, including glial and muscle cells, contain at least two distinct types of aggregated intramembrane particles, identified as hemidesmosomes and gap junctions. Hemidesmosomes consist of angular particles irregularly arranged in circular or elongate patches in external leaflets (E-faces), and are associated with a bundle of intermediate filaments extending into the cytoplasm. Hemidesmosomes of specific axons abut on extracellular space at openings in the surrounding glial sheath. Gap junctions are patches of rounder particles in cytoplasmic leaflets (P-faces) and are more uniformly spaced; they have a corresponding array of pits in the complementary E-face. Gap junctions connect processes of adjacent smooth muscle cells, and apparently interconnect glial processes. Thus, different types of cells in the leech C.N.S. have similar intramembrane specializations. Moreover, the hemidesmosomes and gap junctions might, on superficial examination, be confused.

Original languageEnglish
Pages (from-to)805-815
Number of pages11
JournalJournal of Neurocytology
Volume12
Issue number5
DOIs
StatePublished - Oct 1 1983
Externally publishedYes

Fingerprint

Hemidesmosomes
Leeches
Intermediate Filaments
Gap Junctions
Neuroglia
Hirudo medicinalis
Extracellular Space
Muscle Cells
Smooth Muscle Myocytes
Axons
Cytoplasm
Cell Membrane

ASJC Scopus subject areas

  • Neuroscience(all)
  • Histology
  • Anatomy
  • Cell Biology

Cite this

Distinctions between gap junctions and sites of intermediate filament attachment in the leech C.N.S. / Pumplin, David W.; Muller, Kenneth J.

In: Journal of Neurocytology, Vol. 12, No. 5, 01.10.1983, p. 805-815.

Research output: Contribution to journalArticle

@article{f53514527ffa4858bca7b436e641c14c,
title = "Distinctions between gap junctions and sites of intermediate filament attachment in the leech C.N.S.",
abstract = "Freeze-fracture studies on the nerve cord of the leech Hirudo medicinalis reveal that the plasma membranes of various cells, including glial and muscle cells, contain at least two distinct types of aggregated intramembrane particles, identified as hemidesmosomes and gap junctions. Hemidesmosomes consist of angular particles irregularly arranged in circular or elongate patches in external leaflets (E-faces), and are associated with a bundle of intermediate filaments extending into the cytoplasm. Hemidesmosomes of specific axons abut on extracellular space at openings in the surrounding glial sheath. Gap junctions are patches of rounder particles in cytoplasmic leaflets (P-faces) and are more uniformly spaced; they have a corresponding array of pits in the complementary E-face. Gap junctions connect processes of adjacent smooth muscle cells, and apparently interconnect glial processes. Thus, different types of cells in the leech C.N.S. have similar intramembrane specializations. Moreover, the hemidesmosomes and gap junctions might, on superficial examination, be confused.",
author = "Pumplin, {David W.} and Muller, {Kenneth J}",
year = "1983",
month = "10",
day = "1",
doi = "10.1007/BF01258152",
language = "English",
volume = "12",
pages = "805--815",
journal = "Journal of Neurocytology",
issn = "0300-4864",
publisher = "Kluwer Academic Publishers",
number = "5",

}

TY - JOUR

T1 - Distinctions between gap junctions and sites of intermediate filament attachment in the leech C.N.S.

AU - Pumplin, David W.

AU - Muller, Kenneth J

PY - 1983/10/1

Y1 - 1983/10/1

N2 - Freeze-fracture studies on the nerve cord of the leech Hirudo medicinalis reveal that the plasma membranes of various cells, including glial and muscle cells, contain at least two distinct types of aggregated intramembrane particles, identified as hemidesmosomes and gap junctions. Hemidesmosomes consist of angular particles irregularly arranged in circular or elongate patches in external leaflets (E-faces), and are associated with a bundle of intermediate filaments extending into the cytoplasm. Hemidesmosomes of specific axons abut on extracellular space at openings in the surrounding glial sheath. Gap junctions are patches of rounder particles in cytoplasmic leaflets (P-faces) and are more uniformly spaced; they have a corresponding array of pits in the complementary E-face. Gap junctions connect processes of adjacent smooth muscle cells, and apparently interconnect glial processes. Thus, different types of cells in the leech C.N.S. have similar intramembrane specializations. Moreover, the hemidesmosomes and gap junctions might, on superficial examination, be confused.

AB - Freeze-fracture studies on the nerve cord of the leech Hirudo medicinalis reveal that the plasma membranes of various cells, including glial and muscle cells, contain at least two distinct types of aggregated intramembrane particles, identified as hemidesmosomes and gap junctions. Hemidesmosomes consist of angular particles irregularly arranged in circular or elongate patches in external leaflets (E-faces), and are associated with a bundle of intermediate filaments extending into the cytoplasm. Hemidesmosomes of specific axons abut on extracellular space at openings in the surrounding glial sheath. Gap junctions are patches of rounder particles in cytoplasmic leaflets (P-faces) and are more uniformly spaced; they have a corresponding array of pits in the complementary E-face. Gap junctions connect processes of adjacent smooth muscle cells, and apparently interconnect glial processes. Thus, different types of cells in the leech C.N.S. have similar intramembrane specializations. Moreover, the hemidesmosomes and gap junctions might, on superficial examination, be confused.

UR - http://www.scopus.com/inward/record.url?scp=0020627497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020627497&partnerID=8YFLogxK

U2 - 10.1007/BF01258152

DO - 10.1007/BF01258152

M3 - Article

C2 - 6644356

AN - SCOPUS:0020627497

VL - 12

SP - 805

EP - 815

JO - Journal of Neurocytology

JF - Journal of Neurocytology

SN - 0300-4864

IS - 5

ER -