Distinct protein targets for signals acting at the c-fos serum response element

Regina M Graham, Michael Gilman

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

The c-fos serum response element (SRE) is a primary nuclear target for intracellular signal transduction pathways triggered by growth factors. It is the target for both protein kinase C (PKC)-dependent and -independent signals. Function of the SRE requires binding of a cellular protein, termed serum response factor (SRF). A second protein, p62TCF, recognizes the SRE-SRF complex to form a ternary complex. A mutated SRE that bound SRF but failed to form the ternary complex selectively lost response to PKC activators, but retained response to PKC-independent signals. Thus, two different signaling pathways act through discrete nuclear targets at the SRE. At least one of these pathways functions by recruitment of a pathway-specific accessory factor (p62TCF). These results offer a molecular mechanism to account for the biological specificity of signals that appear to act through common DNA sequence elements.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalScience
Volume251
Issue number4990
StatePublished - Jan 11 1991
Externally publishedYes

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Serum Response Element
Serum Response Factor
Protein Kinase C
Proteins
Signal Transduction
Intercellular Signaling Peptides and Proteins

ASJC Scopus subject areas

  • General

Cite this

Distinct protein targets for signals acting at the c-fos serum response element. / Graham, Regina M; Gilman, Michael.

In: Science, Vol. 251, No. 4990, 11.01.1991, p. 189-192.

Research output: Contribution to journalArticle

Graham, Regina M ; Gilman, Michael. / Distinct protein targets for signals acting at the c-fos serum response element. In: Science. 1991 ; Vol. 251, No. 4990. pp. 189-192.
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