Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse: Multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS

Ancha Baranova, Marianne Hammarsund, Dmitry V Ivanov, Mikhail Skoblov, Olle Sangfelt, Martin Corcoran, Tatiana Borodina, Natalia Makeeva, Anna Pestova, Tatiana Tyazhelova, Svetlana Nazarenko, Francesco Gorreta, Tariq Alsheddi, Karen Schlauch, Eugene Nikitin, Bagrat Kapanadze, Dmitry Shagin, Andrey Poltaraus, Andrey Ivanovich Vorobiev, Eugene ZabarovskySergey Lukianov, Vikas Chandhoke, Rachel Ibbotson, David Oscier, Stefan Einhorn, Dan Grander, Nick Yankovsky

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In the present study, we describe the human and mouse RFP2 gene structure, multiple RFP2 mRNA isoforms in the two species that have different 5′ UTRs and a human-specific antisense transcript RFP2OS. Since the human RFP2 5′ UTR is not conserved in mouse, these findings might indicate a different regulation of RFP2 in the two species. The predicted human and mouse RFP2 proteins are shown to contain a tripartite RING finger-B-box-coiled-coil domain (RBCC), also known as a TRIM domain, and therefore belong to a subgroup of RING finger proteins that are often involved in developmental and tumorigenic processes. Because homozygous deletions of chromosomal region 13q14.3 are found in a number of malignancies, including chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), we suggest that RFP2 might be involved in tumor development. This study provides necessary information for evaluation of the role of RFP2 in malignant transformation and other biological processes.

Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalGene
Volume321
Issue number1-2
DOIs
StatePublished - Dec 4 2003
Externally publishedYes

Fingerprint

RNA Isoforms
Tumor Suppressor Genes
5' Untranslated Regions
Biological Phenomena
B-Cell Chronic Lymphocytic Leukemia
Multiple Myeloma
Neoplasms
Genes
Proteins

Keywords

  • 13q14.3
  • Chronic lymphocytic leukemia (CLL)
  • Mammalian orthologous genes
  • Opposite strand-encoded mRNA
  • RING-B-box-coiled-coil (RBCC) domain

ASJC Scopus subject areas

  • Genetics

Cite this

Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse : Multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS. / Baranova, Ancha; Hammarsund, Marianne; Ivanov, Dmitry V; Skoblov, Mikhail; Sangfelt, Olle; Corcoran, Martin; Borodina, Tatiana; Makeeva, Natalia; Pestova, Anna; Tyazhelova, Tatiana; Nazarenko, Svetlana; Gorreta, Francesco; Alsheddi, Tariq; Schlauch, Karen; Nikitin, Eugene; Kapanadze, Bagrat; Shagin, Dmitry; Poltaraus, Andrey; Vorobiev, Andrey Ivanovich; Zabarovsky, Eugene; Lukianov, Sergey; Chandhoke, Vikas; Ibbotson, Rachel; Oscier, David; Einhorn, Stefan; Grander, Dan; Yankovsky, Nick.

In: Gene, Vol. 321, No. 1-2, 04.12.2003, p. 103-112.

Research output: Contribution to journalArticle

Baranova, A, Hammarsund, M, Ivanov, DV, Skoblov, M, Sangfelt, O, Corcoran, M, Borodina, T, Makeeva, N, Pestova, A, Tyazhelova, T, Nazarenko, S, Gorreta, F, Alsheddi, T, Schlauch, K, Nikitin, E, Kapanadze, B, Shagin, D, Poltaraus, A, Vorobiev, AI, Zabarovsky, E, Lukianov, S, Chandhoke, V, Ibbotson, R, Oscier, D, Einhorn, S, Grander, D & Yankovsky, N 2003, 'Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse: Multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS', Gene, vol. 321, no. 1-2, pp. 103-112. https://doi.org/10.1016/j.gene.2003.08.007
Baranova, Ancha ; Hammarsund, Marianne ; Ivanov, Dmitry V ; Skoblov, Mikhail ; Sangfelt, Olle ; Corcoran, Martin ; Borodina, Tatiana ; Makeeva, Natalia ; Pestova, Anna ; Tyazhelova, Tatiana ; Nazarenko, Svetlana ; Gorreta, Francesco ; Alsheddi, Tariq ; Schlauch, Karen ; Nikitin, Eugene ; Kapanadze, Bagrat ; Shagin, Dmitry ; Poltaraus, Andrey ; Vorobiev, Andrey Ivanovich ; Zabarovsky, Eugene ; Lukianov, Sergey ; Chandhoke, Vikas ; Ibbotson, Rachel ; Oscier, David ; Einhorn, Stefan ; Grander, Dan ; Yankovsky, Nick. / Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse : Multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS. In: Gene. 2003 ; Vol. 321, No. 1-2. pp. 103-112.
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AU - Hammarsund, Marianne

AU - Ivanov, Dmitry V

AU - Skoblov, Mikhail

AU - Sangfelt, Olle

AU - Corcoran, Martin

AU - Borodina, Tatiana

AU - Makeeva, Natalia

AU - Pestova, Anna

AU - Tyazhelova, Tatiana

AU - Nazarenko, Svetlana

AU - Gorreta, Francesco

AU - Alsheddi, Tariq

AU - Schlauch, Karen

AU - Nikitin, Eugene

AU - Kapanadze, Bagrat

AU - Shagin, Dmitry

AU - Poltaraus, Andrey

AU - Vorobiev, Andrey Ivanovich

AU - Zabarovsky, Eugene

AU - Lukianov, Sergey

AU - Chandhoke, Vikas

AU - Ibbotson, Rachel

AU - Oscier, David

AU - Einhorn, Stefan

AU - Grander, Dan

AU - Yankovsky, Nick

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N2 - In the present study, we describe the human and mouse RFP2 gene structure, multiple RFP2 mRNA isoforms in the two species that have different 5′ UTRs and a human-specific antisense transcript RFP2OS. Since the human RFP2 5′ UTR is not conserved in mouse, these findings might indicate a different regulation of RFP2 in the two species. The predicted human and mouse RFP2 proteins are shown to contain a tripartite RING finger-B-box-coiled-coil domain (RBCC), also known as a TRIM domain, and therefore belong to a subgroup of RING finger proteins that are often involved in developmental and tumorigenic processes. Because homozygous deletions of chromosomal region 13q14.3 are found in a number of malignancies, including chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), we suggest that RFP2 might be involved in tumor development. This study provides necessary information for evaluation of the role of RFP2 in malignant transformation and other biological processes.

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