Distal pancreatectomy for benign and low grade malignant tumors: Short-term postoperative outcomes of spleen preservation—A systematic review and update meta-analysis

Fiorella Pendola, Rahul Gadde, Caroline Ripat, Rishika Sharma, Omar Picado, Laila Lobo, Danny Sleeman, Alan Livingstone, Nipun Merchant, Danny Yakoub

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background: The value of spleen preservation with distal pancreatectomy (DP) for benign and low grade malignant tumors remains unclear. The aim of this study was to evaluate the short-term postoperative clinical outcomes in patients undergoing DP with splenectomy (DPS) or spleen preservation (SPDP). Methods: Online database search was performed (2000 to present); key bibliographies were reviewed. Studies comparing patients undergoing DP with either DPS or SPDP, and assessing postoperative complications were included. Results: Meta-analysis of included data showed SPDP patients had significantly less operative blood loss, shorter duration of hospitalization, lower incidence of fluid collection and abscess, lower incidence of postoperative splenic and portal vein thrombosis, and lower incidence of new onset postoperative diabetes. For the whole group, there was no difference in incidence of postoperative pancreatic fistula (POPF) (RR = 0.95; 95%CI 0.65–1.40, P = 0.80), however, subgroup analysis of studies using ISGPF criteria showed that DPS patients had increased rates of Grade B/C POPF (RR = 1.35; 95%CI 1.08–1.70, P = 0.01). Conclusions: SPDP for benign and low grade malignant tumors is associated with shorter hospital stay and decreased morbidity compared to DPS. J. Surg. Oncol. 2017;115:137–143.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalJournal of Surgical Oncology
Volume115
Issue number2
DOIs
StatePublished - Feb 1 2017

Keywords

  • distal pancreatectomy
  • postoperative pancreatic fistula
  • spleen preserving distal pancreatectomy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Fingerprint Dive into the research topics of 'Distal pancreatectomy for benign and low grade malignant tumors: Short-term postoperative outcomes of spleen preservation—A systematic review and update meta-analysis'. Together they form a unique fingerprint.

  • Cite this