Dissociation of effects of LH-RH analogs on pituitary regulation and reproductive behavior

Abba J. Kastin, David H. Coy, Andrew V. Schally, James E. Zadina

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Analogs of LH-RH were studied for their effect on lordosis in ovariectomized rats primed with estrogen. Classified by their gonadotropin-releasing activity, representatives of three types of analogs were tested for facilitation of lordotic (L) responses of preselected females to mounting (M) by male studs. Positive responses (L/M>0.5) were found after SC administration of LH-RH peptides modified so as to be inhibitory, stimulatory, or inactive in releasing LH and FSH. The results further support the concept of a dissociation between the endocrine and extra-endocrine effects of peripherally injected hypothalamic peptides.

Original languageEnglish (US)
Pages (from-to)913-914
Number of pages2
JournalPharmacology, Biochemistry and Behavior
Volume13
Issue number6
DOIs
StatePublished - Dec 1980
Externally publishedYes

Keywords

  • Behavior
  • Hypothalamus
  • LH-RH
  • Lordosis
  • Mating
  • Peptides
  • Pituitary

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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