Dissociable connectivity within human angular gyrus and intraparietal sulcus: Evidence from functional and structural connectivity

Lucina Q. Uddin, Kaustubh Supekar, Hitha Amin, Elena Rykhlevskaia, Daniel A. Nguyen, Michael D. Greicius, Vinod Menon

Research output: Contribution to journalArticle

273 Scopus citations

Abstract

The inferior parietal lobule (IPL) of the human brain is a heterogeneous region involved in visuospatial attention, memory, and mathematical cognition. Detailed description of connectivity profiles of subdivisions within the IPL is critical for accurate interpretation of functional neuroimaging studies involving this region. We separately examined functional and structural connectivity of the angular gyrus (AG) and the intraparietal sulcus (IPS) using probabilistic cytoarchitectonic maps. Regions-of-interest (ROIs) included anterior and posterior AG subregions (PGa, PGp) and 3 IPS subregions (hIP2, hIP1, and hIP3). Resting-state functional connectivity analyses showed that PGa was more strongly linked to basal ganglia, ventral premotor areas, and ventrolateral prefrontal cortex, while PGp was more strongly connected with ventromedial prefrontal cortex, posterior cingulate, and hippocampus - regions comprising the default mode network. The anterior-most IPS ROIs, hIP2 and hIP1, were linked with ventral premotor and middle frontal gyrus, while the posterior-most IPS ROI, hIP3, showed connectivity with extrastriate visual areas. In addition, hIP1 was connected with the insula. Tractography using diffusion tensor imaging revealed structural connectivity between most of these functionally connected regions. Our findings provide evidence for functional heterogeneity of cytoarchitectonically defined subdivisions within IPL and offer a novel framework for synthesis and interpretation of the task-related activations and deactivations involving the IPL during cognition.

Original languageEnglish (US)
Pages (from-to)2636-2646
Number of pages11
JournalCerebral Cortex
Volume20
Issue number11
DOIs
StatePublished - Nov 2010

Keywords

  • Brodmann area 39
  • attention
  • default mode network
  • inferior parietal lobule
  • mathematical cognition

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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