Dissimilar length-tension relations of canine ventricular muscle and false tendon: Electrophysiologic alterations accompanying deformation

Richard Sanders, Robert J Myerburg, Henry Gelband, Arthur L. Bassett

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Length-passive tension (strain-stress) relations were determined in right ventricular trabeculae and right and left ventricular false tendons removed from dog hearts. Preparations were isolated in tissue bath (1 Hz; 36°C) and resting length was progressively increased. False tendons are more compliant than ventricular muscle, requiring a greater increase in length to reach a specified resting tension. The difference in compliance was significant (P < 0.05) at extensions of 40% or more. Right ventricular false tendons are slightly more compliant than left ventricular false tendons; the differences become significant (P < 0.05) at an extension of 40%. The apex of the length-active force relation occurred at greater extensions in false tendon. Scanning electron microscopy demonstrates that extensions of 40 to 50% orient contractile elements uniformly parallel in ventricular muscle while in false tendon undulations remain at these extensions. Stretch caused alterations in resting and action potentials (during stimulation at 1 Hz) of seven false tendons studied with microelectrodes (three of the false tendons demonstrated automatic rhythms) and four of six ventricular muscles. The strains at which the electrical changes occurred were similar in muscle and false tendon (∼65%).

Original languageEnglish
JournalJournal of Molecular and Cellular Cardiology
Volume11
Issue number2
DOIs
StatePublished - Jan 1 1979

Fingerprint

Tendons
Canidae
Muscles
Microelectrodes
Baths
Membrane Potentials
Electron Scanning Microscopy
Action Potentials
Compliance
Dogs

Keywords

  • Abberant electrical activity
  • Active tension
  • Automaticity
  • Canine ventricular muscle
  • False tendon
  • Length-tension relations
  • Resting and action potential
  • Stretch

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Dissimilar length-tension relations of canine ventricular muscle and false tendon : Electrophysiologic alterations accompanying deformation. / Sanders, Richard; Myerburg, Robert J; Gelband, Henry; Bassett, Arthur L.

In: Journal of Molecular and Cellular Cardiology, Vol. 11, No. 2, 01.01.1979.

Research output: Contribution to journalArticle

@article{5e7a8d1fcb3a475d9ce3e4f86556e500,
title = "Dissimilar length-tension relations of canine ventricular muscle and false tendon: Electrophysiologic alterations accompanying deformation",
abstract = "Length-passive tension (strain-stress) relations were determined in right ventricular trabeculae and right and left ventricular false tendons removed from dog hearts. Preparations were isolated in tissue bath (1 Hz; 36°C) and resting length was progressively increased. False tendons are more compliant than ventricular muscle, requiring a greater increase in length to reach a specified resting tension. The difference in compliance was significant (P < 0.05) at extensions of 40{\%} or more. Right ventricular false tendons are slightly more compliant than left ventricular false tendons; the differences become significant (P < 0.05) at an extension of 40{\%}. The apex of the length-active force relation occurred at greater extensions in false tendon. Scanning electron microscopy demonstrates that extensions of 40 to 50{\%} orient contractile elements uniformly parallel in ventricular muscle while in false tendon undulations remain at these extensions. Stretch caused alterations in resting and action potentials (during stimulation at 1 Hz) of seven false tendons studied with microelectrodes (three of the false tendons demonstrated automatic rhythms) and four of six ventricular muscles. The strains at which the electrical changes occurred were similar in muscle and false tendon (∼65{\%}).",
keywords = "Abberant electrical activity, Active tension, Automaticity, Canine ventricular muscle, False tendon, Length-tension relations, Resting and action potential, Stretch",
author = "Richard Sanders and Myerburg, {Robert J} and Henry Gelband and Bassett, {Arthur L.}",
year = "1979",
month = "1",
day = "1",
doi = "10.1016/0022-2828(79)90465-6",
language = "English",
volume = "11",
journal = "Journal of Molecular and Cellular Cardiology",
issn = "0022-2828",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Dissimilar length-tension relations of canine ventricular muscle and false tendon

T2 - Electrophysiologic alterations accompanying deformation

AU - Sanders, Richard

AU - Myerburg, Robert J

AU - Gelband, Henry

AU - Bassett, Arthur L.

PY - 1979/1/1

Y1 - 1979/1/1

N2 - Length-passive tension (strain-stress) relations were determined in right ventricular trabeculae and right and left ventricular false tendons removed from dog hearts. Preparations were isolated in tissue bath (1 Hz; 36°C) and resting length was progressively increased. False tendons are more compliant than ventricular muscle, requiring a greater increase in length to reach a specified resting tension. The difference in compliance was significant (P < 0.05) at extensions of 40% or more. Right ventricular false tendons are slightly more compliant than left ventricular false tendons; the differences become significant (P < 0.05) at an extension of 40%. The apex of the length-active force relation occurred at greater extensions in false tendon. Scanning electron microscopy demonstrates that extensions of 40 to 50% orient contractile elements uniformly parallel in ventricular muscle while in false tendon undulations remain at these extensions. Stretch caused alterations in resting and action potentials (during stimulation at 1 Hz) of seven false tendons studied with microelectrodes (three of the false tendons demonstrated automatic rhythms) and four of six ventricular muscles. The strains at which the electrical changes occurred were similar in muscle and false tendon (∼65%).

AB - Length-passive tension (strain-stress) relations were determined in right ventricular trabeculae and right and left ventricular false tendons removed from dog hearts. Preparations were isolated in tissue bath (1 Hz; 36°C) and resting length was progressively increased. False tendons are more compliant than ventricular muscle, requiring a greater increase in length to reach a specified resting tension. The difference in compliance was significant (P < 0.05) at extensions of 40% or more. Right ventricular false tendons are slightly more compliant than left ventricular false tendons; the differences become significant (P < 0.05) at an extension of 40%. The apex of the length-active force relation occurred at greater extensions in false tendon. Scanning electron microscopy demonstrates that extensions of 40 to 50% orient contractile elements uniformly parallel in ventricular muscle while in false tendon undulations remain at these extensions. Stretch caused alterations in resting and action potentials (during stimulation at 1 Hz) of seven false tendons studied with microelectrodes (three of the false tendons demonstrated automatic rhythms) and four of six ventricular muscles. The strains at which the electrical changes occurred were similar in muscle and false tendon (∼65%).

KW - Abberant electrical activity

KW - Active tension

KW - Automaticity

KW - Canine ventricular muscle

KW - False tendon

KW - Length-tension relations

KW - Resting and action potential

KW - Stretch

UR - http://www.scopus.com/inward/record.url?scp=0018397278&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018397278&partnerID=8YFLogxK

U2 - 10.1016/0022-2828(79)90465-6

DO - 10.1016/0022-2828(79)90465-6

M3 - Article

C2 - 423264

AN - SCOPUS:0018397278

VL - 11

JO - Journal of Molecular and Cellular Cardiology

JF - Journal of Molecular and Cellular Cardiology

SN - 0022-2828

IS - 2

ER -