Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

M. Wakamiya, M. R. Blackburn, Roland Jurecic, M. J. McArthur, R. S. Geske, J. Cartwright, K. Mitani, S. Vaishnav, J. W. Belmont, R. E. Kellems, M. J. Finegold, C. A. Montgomery, A. Bradley, C. T. Caskey

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

We have generated mice with a null mutation at the Ada locus, which encodes the purine catabolic enzyme adenosine deaminase (ADA, EC 3.5.4.4). ADA-deficient fetuses exhibited hepatocellular impairment and died perinatally. Their lymphoid tissues were not largely affected. Accumulation of ADA substrates was detectable in ADA-deficient conceptuses as early as 12.5 days postcoitum, dramatically increasing during late in utero development, and is the likely cause of liver damage and fetal death. The results presented here demonstrate that ADA is important for the homeostatic maintenance of purines in mice.

Original languageEnglish
Pages (from-to)3673-3677
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number9
StatePublished - Jan 1 1995
Externally publishedYes

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Adenosine Deaminase
Purines
Fetal Death
Lymphoid Tissue
Genes
Fetus
Maintenance
Mutation
Liver
Enzymes
purine

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice. / Wakamiya, M.; Blackburn, M. R.; Jurecic, Roland; McArthur, M. J.; Geske, R. S.; Cartwright, J.; Mitani, K.; Vaishnav, S.; Belmont, J. W.; Kellems, R. E.; Finegold, M. J.; Montgomery, C. A.; Bradley, A.; Caskey, C. T.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, No. 9, 01.01.1995, p. 3673-3677.

Research output: Contribution to journalArticle

Wakamiya, M, Blackburn, MR, Jurecic, R, McArthur, MJ, Geske, RS, Cartwright, J, Mitani, K, Vaishnav, S, Belmont, JW, Kellems, RE, Finegold, MJ, Montgomery, CA, Bradley, A & Caskey, CT 1995, 'Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice', Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 9, pp. 3673-3677.
Wakamiya, M. ; Blackburn, M. R. ; Jurecic, Roland ; McArthur, M. J. ; Geske, R. S. ; Cartwright, J. ; Mitani, K. ; Vaishnav, S. ; Belmont, J. W. ; Kellems, R. E. ; Finegold, M. J. ; Montgomery, C. A. ; Bradley, A. ; Caskey, C. T. / Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice. In: Proceedings of the National Academy of Sciences of the United States of America. 1995 ; Vol. 92, No. 9. pp. 3673-3677.
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