Dispositional optimism and stress-induced changes in immunity and negative mood

Lena Brydon, Cicely Walker, Andrew Wawrzyniak, Henrik Chart, Andrew Steptoe

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Evidence suggests that optimism may be protective for health during times of heightened stress, yet the mechanisms involved remain unclear. In a double-blind placebo-controlled study, we recently showed that acute psychological stress and an immune stimulus (Typhim-Vi typhoid vaccine) synergistically increased serum levels of interleukin-6 (IL-6) and negative mood in 59 healthy men. Here we carried out further analysis of this sample to investigate the relationship between dispositional optimism and stress-induced changes in immunity and mood. Volunteers were randomly assigned to one of four experimental conditions in which they received either typhoid vaccine or saline placebo, and then rested or completed two mental tasks. In the stress condition, optimism was inversely related to IL-6 responses, independent of age, BMI, trait CES-D depression and baseline IL-6. This relationship was present across both stress groups (combining vaccine and placebo) and was not present in the vaccine/stress group alone, suggesting that optimism protects against the inflammatory effects of stress rather than vaccine per se. Typhoid vaccine induced a significant increase in participants' circulating anti-Vi antibody levels. Stress had no effect on antibody responses overall. However, in the vaccine/stress group, there was a strong positive association between optimism and antibody responses, indicating that stress accentuated the antibody response to vaccine in optimists. Across the complete sample, more optimistic individuals had smaller increases in negative mood and less reduction in mental vigour. Together these findings suggest that optimism may promote health, by counteracting stress-induced increases in inflammation and boosting the adjuvant effects of acute stress.

Original languageEnglish
Pages (from-to)810-816
Number of pages7
JournalBrain, Behavior, and Immunity
Volume23
Issue number6
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

Fingerprint

Immunity
Typhoid-Paratyphoid Vaccines
Vaccines
Antibody Formation
Interleukin-6
Placebos
Health
Psychological Stress
Optimism
Volunteers
Anti-Idiotypic Antibodies
Depression
Inflammation
Serum

Keywords

  • IL-6
  • Immune response
  • Mood
  • Optimism
  • Psychological stress
  • Vaccination

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Dispositional optimism and stress-induced changes in immunity and negative mood. / Brydon, Lena; Walker, Cicely; Wawrzyniak, Andrew; Chart, Henrik; Steptoe, Andrew.

In: Brain, Behavior, and Immunity, Vol. 23, No. 6, 01.08.2009, p. 810-816.

Research output: Contribution to journalArticle

Brydon, Lena ; Walker, Cicely ; Wawrzyniak, Andrew ; Chart, Henrik ; Steptoe, Andrew. / Dispositional optimism and stress-induced changes in immunity and negative mood. In: Brain, Behavior, and Immunity. 2009 ; Vol. 23, No. 6. pp. 810-816.
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