In patients with germinal aplasia or 'Sertoli cell only' syndrome (Del Castillo syndrome) basal FSH serum levels were higher in comparison with normal adult males; however, basal LH concentration was similar. Synthetic LRH administration elicited an augmented FSH response and normal LH response when compared to that observed in normal adult men. These data indicate that in cases of selective germinal aplasia in the presence of normal Sertoli and Leydig cells, the FSH secretory response to LRH is enhanced, which may reflect a separate gonadal feedback control for FSH and LH secretion.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry
- Biochemistry, medical