Disparity in the negative gonadal feedback control for LH and FSH secretion in cases of germinal aplasia or sertoli-cell-only syndrome

Arturo Zárate; José Garrido; Elías S. Canales; Jorge Soria; Andrew V. Schally

doi:10.1210/jcem-38-6-1125

Disparity in the negative gonadal feedback control for LH and FSH secretion in cases of germinal aplasia or sertoli-cell-only syndrome

Arturo Zárate, José Garrido, Elías S. Canales, Jorge Soria, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In patients with germinal aplasia or 'Sertoli cell only' syndrome (Del Castillo syndrome) basal FSH serum levels were higher in comparison with normal adult males; however, basal LH concentration was similar. Synthetic LRH administration elicited an augmented FSH response and normal LH response when compared to that observed in normal adult men. These data indicate that in cases of selective germinal aplasia in the presence of normal Sertoli and Leydig cells, the FSH secretory response to LRH is enhanced, which may reflect a separate gonadal feedback control for FSH and LH secretion.

Original language	English (US)
Pages (from-to)	1125-1127
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	38
Issue number	6
DOIs	https://doi.org/10.1210/jcem-38-6-1125
State	Published - Jan 1 1974
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1210/jcem-38-6-1125

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Disparity in the negative gonadal feedback control for LH and FSH secretion in cases of germinal aplasia or sertoli-cell-only syndrome. / Zárate, Arturo; Garrido, José; Canales, Elías S.; Soria, Jorge; Schally, Andrew V.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 38, No. 6, 01.01.1974, p. 1125-1127.

Research output: Contribution to journal › Article › peer-review

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abstract = "In patients with germinal aplasia or 'Sertoli cell only' syndrome (Del Castillo syndrome) basal FSH serum levels were higher in comparison with normal adult males; however, basal LH concentration was similar. Synthetic LRH administration elicited an augmented FSH response and normal LH response when compared to that observed in normal adult men. These data indicate that in cases of selective germinal aplasia in the presence of normal Sertoli and Leydig cells, the FSH secretory response to LRH is enhanced, which may reflect a separate gonadal feedback control for FSH and LH secretion.",

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AU - Canales, Elías S.

AU - Soria, Jorge

AU - Schally, Andrew V.

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N2 - In patients with germinal aplasia or 'Sertoli cell only' syndrome (Del Castillo syndrome) basal FSH serum levels were higher in comparison with normal adult males; however, basal LH concentration was similar. Synthetic LRH administration elicited an augmented FSH response and normal LH response when compared to that observed in normal adult men. These data indicate that in cases of selective germinal aplasia in the presence of normal Sertoli and Leydig cells, the FSH secretory response to LRH is enhanced, which may reflect a separate gonadal feedback control for FSH and LH secretion.

AB - In patients with germinal aplasia or 'Sertoli cell only' syndrome (Del Castillo syndrome) basal FSH serum levels were higher in comparison with normal adult males; however, basal LH concentration was similar. Synthetic LRH administration elicited an augmented FSH response and normal LH response when compared to that observed in normal adult men. These data indicate that in cases of selective germinal aplasia in the presence of normal Sertoli and Leydig cells, the FSH secretory response to LRH is enhanced, which may reflect a separate gonadal feedback control for FSH and LH secretion.

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Disparity in the negative gonadal feedback control for LH and FSH secretion in cases of germinal aplasia or sertoli-cell-only syndrome

Abstract

ASJC Scopus subject areas

UN SDGs

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