Disparity in the negative gonadal feedback control for LH and FSH secretion in cases of germinal aplasia or sertoli-cell-only syndrome

Arturo Zárate, José Garrido, Elías S. Canales, Jorge Soria, Andrew V. Schally

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

In patients with germinal aplasia or 'Sertoli cell only' syndrome (Del Castillo syndrome) basal FSH serum levels were higher in comparison with normal adult males; however, basal LH concentration was similar. Synthetic LRH administration elicited an augmented FSH response and normal LH response when compared to that observed in normal adult men. These data indicate that in cases of selective germinal aplasia in the presence of normal Sertoli and Leydig cells, the FSH secretory response to LRH is enhanced, which may reflect a separate gonadal feedback control for FSH and LH secretion.

Original languageEnglish (US)
Pages (from-to)1125-1127
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume38
Issue number6
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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