Disparities in care among patients with low-grade serous ovarian carcinoma

J. Siemon, J. Galli, B. Slomovitz, M. Schlumbrecht

Research output: Contribution to journalArticle

Abstract

Objective: Low-grade serous carcinoma (LGSC) is a rare histotype of ovarian cancer with a unique disease course. Little data exist regarding the influence of sociodemographic factors on diagnosis and outcomes in this disease. Our objective was to evaluate the associations between these factors and the clinical characteristics, treatment approaches, and survival in LGSC. Methods: The National Cancer Database (NCDB) was queried for data between 2004 and 2015 on patients with LGSC. LGSC was inclusive of invasive, grade 1, serous carcinoma of the ovary, fallopian tube, or peritoneum. Patient demographics, insurance status, disease characteristics, treatment approach, and survival were evaluated. ANOVA, Chi Square, Kaplan-Meier, and Cox regression were used in the analysis. Results: 3221 patients with LGSC were evaluated (89.5% White, 6.2% Black; 7.2% Hispanic, 92.8% non-Hispanic). Compared to Whites, Blacks were diagnosed younger (50.4 vs. 55.9 years, p < 0.01), received less chemotherapy (61.8% vs 67.0%, p = 0.04), and had less CA-125 elevation (OR 4.14 [1.26–13.57], p = 0.02). Compared to non-Hispanics, Hispanics were younger (49.5 vs. 55.8 years, p < 0.01) and received less chemotherapy (55% vs 67%, p < 0.001). In contrast to private insurance, government insurance was associated with a higher 30-day mortality (1.5% vs 0.01%, p < 0.001). Race/ethnicity were not predictive of OS, while older age (HR 1.013 [1.002–1.024], p = 0.03), advanced stage (HR 3.09 [2.15–4.43], p < 0.001), and government insurance (HR 2.33 [1.65–3.30], p < 0.001) were all independently associated with worse OS. Conclusions: Significant differences exist in the clinical characteristics, treatments, and outcomes of LGSC by sociodemographics, with Blacks and Hispanics being diagnosed younger and receiving less chemotherapy. Age, stage, and insurance status were predictive of overall survival.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
JournalGynecologic oncology
Volume157
Issue number1
DOIs
StatePublished - Apr 2020

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Keywords

  • Age
  • Disparities
  • Ethnic
  • Low-grade serous carcinoma
  • NCDB
  • Ovarian cancer
  • Racial
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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