Disentangling a Bad Reputation: Changing Perceptions of Amyloids

Miling Wang, Timothy E. Audas, Stephen Lee

Research output: Contribution to journalShort surveypeer-review

10 Scopus citations


Historically, amyloids were perceived as toxic/irreversible protein aggregates associated with neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Recent papers are challenging this perception by uncovering widespread cellular roles for physiological amyloidogenesis. These findings suggest that the amyloid-fold should be considered, alongside the native-fold and unfolded configurations, as a physiological and reversible protein organization.

Original languageEnglish (US)
Pages (from-to)465-467
Number of pages3
JournalTrends in Cell Biology
Issue number7
StatePublished - Jul 2017


  • Alzheimer's
  • amyloid
  • dormancy
  • phase transition
  • protein folding

ASJC Scopus subject areas

  • Cell Biology


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