Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

Gangli Gong, Yuli Xie, Yidong Liu, Alison Rinderspacher, Shi Xian Deng, Yan Feng, Zhengxiang Zhu, Yufei Tang, Michael Wyler, Nathalie Aulner, Udo Toebben, Deborah H. Smith, Lars Branden, Caty Chung, Stephan C Schuerer, Dušica Vidović, Donald W. Landry

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.

Original languageEnglish
Pages (from-to)1191-1194
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number4
DOIs
StatePublished - Feb 15 2009
Externally publishedYes

Fingerprint

T-cells
Human Umbilical Vein Endothelial Cells
Molecules
Jurkat Cells
T-Lymphocytes

Keywords

  • Activator
  • HUVEC cells
  • NF-κB
  • Quinazoline

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation. / Gong, Gangli; Xie, Yuli; Liu, Yidong; Rinderspacher, Alison; Deng, Shi Xian; Feng, Yan; Zhu, Zhengxiang; Tang, Yufei; Wyler, Michael; Aulner, Nathalie; Toebben, Udo; Smith, Deborah H.; Branden, Lars; Chung, Caty; Schuerer, Stephan C; Vidović, Dušica; Landry, Donald W.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 4, 15.02.2009, p. 1191-1194.

Research output: Contribution to journalArticle

Gong, G, Xie, Y, Liu, Y, Rinderspacher, A, Deng, SX, Feng, Y, Zhu, Z, Tang, Y, Wyler, M, Aulner, N, Toebben, U, Smith, DH, Branden, L, Chung, C, Schuerer, SC, Vidović, D & Landry, DW 2009, 'Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 4, pp. 1191-1194. https://doi.org/10.1016/j.bmcl.2008.12.086
Gong, Gangli ; Xie, Yuli ; Liu, Yidong ; Rinderspacher, Alison ; Deng, Shi Xian ; Feng, Yan ; Zhu, Zhengxiang ; Tang, Yufei ; Wyler, Michael ; Aulner, Nathalie ; Toebben, Udo ; Smith, Deborah H. ; Branden, Lars ; Chung, Caty ; Schuerer, Stephan C ; Vidović, Dušica ; Landry, Donald W. / Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 4. pp. 1191-1194.
@article{56861df9f41b4f1383f4b06a05d5b738,
title = "Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation",
abstract = "An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.",
keywords = "Activator, HUVEC cells, NF-κB, Quinazoline",
author = "Gangli Gong and Yuli Xie and Yidong Liu and Alison Rinderspacher and Deng, {Shi Xian} and Yan Feng and Zhengxiang Zhu and Yufei Tang and Michael Wyler and Nathalie Aulner and Udo Toebben and Smith, {Deborah H.} and Lars Branden and Caty Chung and Schuerer, {Stephan C} and Dušica Vidović and Landry, {Donald W.}",
year = "2009",
month = "2",
day = "15",
doi = "10.1016/j.bmcl.2008.12.086",
language = "English",
volume = "19",
pages = "1191--1194",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

AU - Gong, Gangli

AU - Xie, Yuli

AU - Liu, Yidong

AU - Rinderspacher, Alison

AU - Deng, Shi Xian

AU - Feng, Yan

AU - Zhu, Zhengxiang

AU - Tang, Yufei

AU - Wyler, Michael

AU - Aulner, Nathalie

AU - Toebben, Udo

AU - Smith, Deborah H.

AU - Branden, Lars

AU - Chung, Caty

AU - Schuerer, Stephan C

AU - Vidović, Dušica

AU - Landry, Donald W.

PY - 2009/2/15

Y1 - 2009/2/15

N2 - An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.

AB - An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.

KW - Activator

KW - HUVEC cells

KW - NF-κB

KW - Quinazoline

UR - http://www.scopus.com/inward/record.url?scp=59649092365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59649092365&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2008.12.086

DO - 10.1016/j.bmcl.2008.12.086

M3 - Article

C2 - 19136257

AN - SCOPUS:59649092365

VL - 19

SP - 1191

EP - 1194

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 4

ER -