Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation

Gangli Gong, Yuli Xie, Yidong Liu, Alison Rinderspacher, Shi Xian Deng, Yan Feng, Zhengxiang Zhu, Yufei Tang, Michael Wyler, Nathalie Aulner, Udo Toebben, Deborah H. Smith, Lars Branden, Caty Chung, Stephan C Schuerer, Dušica Vidović, Donald W. Landry

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

An IKKβ inhibitor reported to block NF-κB transcriptional activities in Jurkat T cells, was found to enhance NF-κB translocation in HUVEC cells. These studies suggested a noncanonical NF-κB signaling pathway independent of IKKβ in HUVEC cells.

Original languageEnglish
Pages (from-to)1191-1194
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number4
DOIs
StatePublished - Feb 15 2009
Externally publishedYes

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Keywords

  • Activator
  • HUVEC cells
  • NF-κB
  • Quinazoline

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation. / Gong, Gangli; Xie, Yuli; Liu, Yidong; Rinderspacher, Alison; Deng, Shi Xian; Feng, Yan; Zhu, Zhengxiang; Tang, Yufei; Wyler, Michael; Aulner, Nathalie; Toebben, Udo; Smith, Deborah H.; Branden, Lars; Chung, Caty; Schuerer, Stephan C; Vidović, Dušica; Landry, Donald W.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 4, 15.02.2009, p. 1191-1194.

Research output: Contribution to journalArticle