Discovery of LHRH and development of LHRH analogs for prostate cancer treatment

Andrew V Schally, Norman L Block, Ferenc G. Rick

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

The discovery, isolation, elucidation of structure, synthesis, and initial testing of the neuropeptide hypothalamic luteinizing hormone-releasing hormone (LHRH), which regulates reproduction, is briefly described. The design, synthesis, and experimental and clinical testing of agonistic analogs of LHRH is extensively reviewed focusing on the development of new methods for the treatment of prostate cancer. Subsequent development of antagonistic analogs of LHRH is then faithfully recounted with special emphasis on therapy of prostate cancer and BPH. The concepts of targeted therapy to peptide receptors on tumors are re-examined and the development of the cytotoxic analogs of LHRH and their status is reviewed. The endeavor to develop better therapies for prostate cancer, based on LHRH analogs, guided much of our work.

Original languageEnglish (US)
Pages (from-to)1036-1054
Number of pages19
JournalProstate
Volume77
Issue number9
DOIs
StatePublished - Jun 15 2017

Keywords

  • advanced prostate cancer
  • androgen deprivation therapy
  • CRPC
  • luteinizing hormone-releasing hormone
  • targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Urology

Fingerprint Dive into the research topics of 'Discovery of LHRH and development of LHRH analogs for prostate cancer treatment'. Together they form a unique fingerprint.

  • Cite this