Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH 2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In this letter, we report the discovery of an orally potent and selective inhibitor of HPGDS that reduces the antigen-induced response in allergic sheep.
- airway allergy, inflammatory processes, cyclooxygenase (COX)
- Hematopoietic prostaglandin D synthase (HPGDS)
- PGH, PGD
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery