Discovery and evaluation of potent, tyrosine-based α4β1 integrin antagonists

Sarah C. Archibald; John C. Head; Neil Gozzard; David W. Howat; Ted A.H. Parton; John R. Porter; Martyn K. Robinson; Anthony Shock; Graham J. Warrellow; William M. Abraham

doi:10.1016/S0960-894X(00)00147-5

Discovery and evaluation of potent, tyrosine-based α4β1 integrin antagonists

Sarah C. Archibald, John C. Head, Neil Gozzard, David W. Howat, Ted A.H. Parton, John R. Porter, Martyn K. Robinson, Anthony Shock, Graham J. Warrellow, William M. Abraham

Medicine

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Using disulphide cysteine-based inhibitors as lead structures, this communication describes our strategy for identifying more stable, potent antagonists of the α4β1 integrin. These studies ultimately discovered potent, low molecular weight inhibitors based on D-thioproline-L-tyrosine. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English (US)
Pages (from-to)	997-999
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	9
DOIs	https://doi.org/10.1016/S0960-894X(00)00147-5
State	Published - May 1 2000

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00147-5

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Discovery and evaluation of potent, tyrosine-based α4β1 integrin antagonists. / Archibald, Sarah C.; Head, John C.; Gozzard, Neil; Howat, David W.; Parton, Ted A.H.; Porter, John R.; Robinson, Martyn K.; Shock, Anthony; Warrellow, Graham J.; Abraham, William M.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 9, 01.05.2000, p. 997-999.

Research output: Contribution to journal › Article › peer-review

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