Discontinuous deletions at 11q23 in B cell chronic lymphocytic leukemia

Y. Zhu, O. Monni, W. El-Rifai, S. M. Siitonen, L. Vilpo, J. Vilpo, S. Knuutila

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Loss of genomic material in 11q is one of the most common structural chromosome aberrations in B cell chronic lymphocytic leukemia (B-CLL). In order to characterize the deletions of 11q23 in B-CLL, we performed fluorescence in situ hybridization (FISH) with eight YAC (yeast artificial chromosome) probes on peripheral leukocytes of 30 patients. These YACs form a contig spanning 7.8 Mb at 11q23.1-q23.3. We found deletions in nine out of 30 cases (30%) and five of them had discontinuous deletions in this region. The region represented by YAC 755b11 (1.6 Mb in size) was involved in all cases with deletions, supporting the hypothesis that this region might contain a novel gene of pathogenic importance to B-CLL. A more distal region represented by YAC 785e12 (760 kb in size) was deleted frequently and specifically. Whether there is another novel gene of pathogenic importance to B-CLL and what is its potential relationship to the deletions in the region represented by YAC 755b11, are issues that require further studies.

Original languageEnglish (US)
Pages (from-to)708-712
Number of pages5
JournalLeukemia
Volume13
Issue number5
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • B cell chronic lymphocytic leukemia
  • Deletions at 11q23
  • Fluorescence in situ hybridization
  • Yeast artificial chromosome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Zhu, Y., Monni, O., El-Rifai, W., Siitonen, S. M., Vilpo, L., Vilpo, J., & Knuutila, S. (1999). Discontinuous deletions at 11q23 in B cell chronic lymphocytic leukemia. Leukemia, 13(5), 708-712. https://doi.org/10.1038/sj.leu.2401405