DISAPPEARANCE OF LH‐RELEASING HORMONE IN MAN AS DETERMINED BY RADIOIMMUNOASSAY

AKIRA ARIMURA; ABBA J. KASTIN; D. GONZALEZ‐BARCENA; JORGE SILLER; ROBERT E. WEAVER; ANDREW V. SCHALLY

doi:10.1111/j.1365-2265.1974.tb02812.x

DISAPPEARANCE OF LH‐RELEASING HORMONE IN MAN AS DETERMINED BY RADIOIMMUNOASSAY

AKIRA ARIMURA, ABBA J. KASTIN, D. GONZALEZ‐BARCENA, JORGE SILLER, ROBERT E. WEAVER, ANDREW V. SCHALLY

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The disappearance of LH releasing hormone (LH-RH) administered i.v. together with inulin was measured by radioimmunoassay. The half time disappearance of 3.6 min for LH RH was significantly shorter than the half time of 14.2 min found for the inulin. On the assumption that diffusion and distribution into the extracellular space and excretion are quantitatively similar for LH RH and inulin, the part of the half life of LH RH due to metabolic breakdown can be calculated to be about 4.8 min. Peak LH and FSH values were found to occur later. The results suggest that most of the immunoreactive LH RH is no longer present in the blood at the time of maximal gonadotropin release and that this is because of rapid metabolism as well as diffusion and excretion.

Original language	English (US)
Pages (from-to)	421-425
Number of pages	5
Journal	Clinical Endocrinology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2265.1974.tb02812.x
State	Published - Oct 1974
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "DISAPPEARANCE OF LH‐RELEASING HORMONE IN MAN AS DETERMINED BY RADIOIMMUNOASSAY",

abstract = "The disappearance of LH releasing hormone (LH-RH) administered i.v. together with inulin was measured by radioimmunoassay. The half time disappearance of 3.6 min for LH RH was significantly shorter than the half time of 14.2 min found for the inulin. On the assumption that diffusion and distribution into the extracellular space and excretion are quantitatively similar for LH RH and inulin, the part of the half life of LH RH due to metabolic breakdown can be calculated to be about 4.8 min. Peak LH and FSH values were found to occur later. The results suggest that most of the immunoreactive LH RH is no longer present in the blood at the time of maximal gonadotropin release and that this is because of rapid metabolism as well as diffusion and excretion.",

author = "AKIRA ARIMURA and KASTIN, {ABBA J.} and D. GONZALEZ‐BARCENA and JORGE SILLER and WEAVER, {ROBERT E.} and SCHALLY, {ANDREW V.}",

year = "1974",

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doi = "10.1111/j.1365-2265.1974.tb02812.x",

language = "English (US)",

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AU - ARIMURA, AKIRA

AU - KASTIN, ABBA J.

AU - GONZALEZ‐BARCENA, D.

AU - SILLER, JORGE

AU - WEAVER, ROBERT E.

AU - SCHALLY, ANDREW V.

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N2 - The disappearance of LH releasing hormone (LH-RH) administered i.v. together with inulin was measured by radioimmunoassay. The half time disappearance of 3.6 min for LH RH was significantly shorter than the half time of 14.2 min found for the inulin. On the assumption that diffusion and distribution into the extracellular space and excretion are quantitatively similar for LH RH and inulin, the part of the half life of LH RH due to metabolic breakdown can be calculated to be about 4.8 min. Peak LH and FSH values were found to occur later. The results suggest that most of the immunoreactive LH RH is no longer present in the blood at the time of maximal gonadotropin release and that this is because of rapid metabolism as well as diffusion and excretion.

AB - The disappearance of LH releasing hormone (LH-RH) administered i.v. together with inulin was measured by radioimmunoassay. The half time disappearance of 3.6 min for LH RH was significantly shorter than the half time of 14.2 min found for the inulin. On the assumption that diffusion and distribution into the extracellular space and excretion are quantitatively similar for LH RH and inulin, the part of the half life of LH RH due to metabolic breakdown can be calculated to be about 4.8 min. Peak LH and FSH values were found to occur later. The results suggest that most of the immunoreactive LH RH is no longer present in the blood at the time of maximal gonadotropin release and that this is because of rapid metabolism as well as diffusion and excretion.

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