The disappearance of LH releasing hormone (LH-RH) administered i.v. together with inulin was measured by radioimmunoassay. The half time disappearance of 3.6 min for LH RH was significantly shorter than the half time of 14.2 min found for the inulin. On the assumption that diffusion and distribution into the extracellular space and excretion are quantitatively similar for LH RH and inulin, the part of the half life of LH RH due to metabolic breakdown can be calculated to be about 4.8 min. Peak LH and FSH values were found to occur later. The results suggest that most of the immunoreactive LH RH is no longer present in the blood at the time of maximal gonadotropin release and that this is because of rapid metabolism as well as diffusion and excretion.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Oct 1974|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism