DISAPPEARANCE OF LH‐RELEASING HORMONE IN MAN AS DETERMINED BY RADIOIMMUNOASSAY

AKIRA ARIMURA, ABBA J. KASTIN, D. GONZALEZ‐BARCENA, JORGE SILLER, ROBERT E. WEAVER, ANDREW V. SCHALLY

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The disappearance of LH releasing hormone (LH-RH) administered i.v. together with inulin was measured by radioimmunoassay. The half time disappearance of 3.6 min for LH RH was significantly shorter than the half time of 14.2 min found for the inulin. On the assumption that diffusion and distribution into the extracellular space and excretion are quantitatively similar for LH RH and inulin, the part of the half life of LH RH due to metabolic breakdown can be calculated to be about 4.8 min. Peak LH and FSH values were found to occur later. The results suggest that most of the immunoreactive LH RH is no longer present in the blood at the time of maximal gonadotropin release and that this is because of rapid metabolism as well as diffusion and excretion.

Original languageEnglish (US)
Pages (from-to)421-425
Number of pages5
JournalClinical Endocrinology
Volume3
Issue number4
DOIs
StatePublished - Oct 1974
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    ARIMURA, AKIRA., KASTIN, ABBA. J., GONZALEZ‐BARCENA, D., SILLER, JORGE., WEAVER, ROBERT. E., & SCHALLY, ANDREW. V. (1974). DISAPPEARANCE OF LH‐RELEASING HORMONE IN MAN AS DETERMINED BY RADIOIMMUNOASSAY. Clinical Endocrinology, 3(4), 421-425. https://doi.org/10.1111/j.1365-2265.1974.tb02812.x