Abstract
Despite the considerable evidence for the CNS actions of α-melanocyte-stimulating hormone (α-MSH) in man, little attention has been given to its half-time disappearance from plasma and urinary excretion in normal individuals. In the first experiment, a healthy man was given 15 μCi of tritiated (3H)-α-MSH as a rapid IV injection. A plot of the disappearance time in plasma was characteristic of a multiexponential curve, the linear components of which were resolved by the subtraction method and half-time disappearance calculated directly from the slope of the regression line. The half-time disappearance was 1 min for the first component and 25 min for the second component. After the IV administration of 50 μCi of 125I-α-MSH in the second experiment, the two components showed halftime disappearances of 1 min and 4.8 min respectively. These times were not changed by precipitation of the plasma with 10% trichloroacetic acid. Thirty-eight percent and 42% of the label appeared in the urine 4 hr after the injection of either 3H-α-MSH or 125I-α-MSH. The results suggest that the persistence of high levels of α-MSH in the blood after injection in man may be too short to fully explain the CNS effects of α-MSH.
| Original language | English |
|---|---|
| Pages (from-to) | 207-212 |
| Number of pages | 6 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1978 |
| Externally published | Yes |
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Keywords
- Half-life
- Hormone
- Peptide
- α-MSH
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Disappearance and excretion of labeled α-MSH in man. / Redding, Tommie W.; Kastin, Abba J.; Nikolics, Karoly; Schally, Andrew V; Coy, David H.
In: Pharmacology, Biochemistry and Behavior, Vol. 9, No. 2, 01.01.1978, p. 207-212.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disappearance and excretion of labeled α-MSH in man
AU - Redding, Tommie W.
AU - Kastin, Abba J.
AU - Nikolics, Karoly
AU - Schally, Andrew V
AU - Coy, David H.
PY - 1978/1/1
Y1 - 1978/1/1
N2 - Despite the considerable evidence for the CNS actions of α-melanocyte-stimulating hormone (α-MSH) in man, little attention has been given to its half-time disappearance from plasma and urinary excretion in normal individuals. In the first experiment, a healthy man was given 15 μCi of tritiated (3H)-α-MSH as a rapid IV injection. A plot of the disappearance time in plasma was characteristic of a multiexponential curve, the linear components of which were resolved by the subtraction method and half-time disappearance calculated directly from the slope of the regression line. The half-time disappearance was 1 min for the first component and 25 min for the second component. After the IV administration of 50 μCi of 125I-α-MSH in the second experiment, the two components showed halftime disappearances of 1 min and 4.8 min respectively. These times were not changed by precipitation of the plasma with 10% trichloroacetic acid. Thirty-eight percent and 42% of the label appeared in the urine 4 hr after the injection of either 3H-α-MSH or 125I-α-MSH. The results suggest that the persistence of high levels of α-MSH in the blood after injection in man may be too short to fully explain the CNS effects of α-MSH.
AB - Despite the considerable evidence for the CNS actions of α-melanocyte-stimulating hormone (α-MSH) in man, little attention has been given to its half-time disappearance from plasma and urinary excretion in normal individuals. In the first experiment, a healthy man was given 15 μCi of tritiated (3H)-α-MSH as a rapid IV injection. A plot of the disappearance time in plasma was characteristic of a multiexponential curve, the linear components of which were resolved by the subtraction method and half-time disappearance calculated directly from the slope of the regression line. The half-time disappearance was 1 min for the first component and 25 min for the second component. After the IV administration of 50 μCi of 125I-α-MSH in the second experiment, the two components showed halftime disappearances of 1 min and 4.8 min respectively. These times were not changed by precipitation of the plasma with 10% trichloroacetic acid. Thirty-eight percent and 42% of the label appeared in the urine 4 hr after the injection of either 3H-α-MSH or 125I-α-MSH. The results suggest that the persistence of high levels of α-MSH in the blood after injection in man may be too short to fully explain the CNS effects of α-MSH.
KW - Half-life
KW - Hormone
KW - Peptide
KW - α-MSH
UR - http://www.scopus.com/inward/record.url?scp=0018196954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018196954&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(78)90166-1
DO - 10.1016/0091-3057(78)90166-1
M3 - Article
C2 - 714971
AN - SCOPUS:0018196954
VL - 9
SP - 207
EP - 212
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 2
ER -