Directing and potentiating stem cell-mediated angiogenesis and tissue repair by cell surface e-selectin coating

Zhao Jun Liu, Pirouz Daftarian, Letícia Kovalski, Bo Wang, Runxia Tian, Diego M. Castilla, Emre Dikici, Victor L. Perez, Sapna Deo, Sylvia Daunert, Omaida C. Velazquez

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Stem cell therapy has emerged as a promising approach for treatment of a number of diseases, including delayed and non-healing wounds. However, targeted systemic delivery of therapeutic cells to the dysfunctional tissues remains one formidable challenge. Herein, we present a targeted nanocarrier-mediated cell delivery method by coating the surface of the cell to be delivered with dendrimer nanocarriers modified with adhesion molecules. Infused nanocarrier-coated cells reach to destination via recognition and association with the counterpart adhesion molecules highly or selectively expressed on the activated endothelium in diseased tissues. Once anchored on the activated endothelium, nanocarriers-coated transporting cells undergo transendothelial migration, extravasation and homing to the targeted tissues to execute their therapeutic role. We now demonstrate feasibility, efficacy and safety of our targeted nanocarrier for delivery of bone marrow cells (BMC) to cutaneous wound tissues and grafted corneas and its advantages over conventional BMC transplantation in mouse models for wound healing and neovascularization. This versatile platform is suited for targeted systemic delivery of virtually any type of therapeutic cell.

Original languageEnglish (US)
Article numbere0154053
JournalPloS one
Volume11
Issue number4
DOIs
StatePublished - Apr 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Directing and potentiating stem cell-mediated angiogenesis and tissue repair by cell surface e-selectin coating'. Together they form a unique fingerprint.

  • Cite this