Direct leukocyte migration inhibition by myelin basic protein in exacerbations of multiple sclerosis

W. Sheremata, H. Triller, J. B.R. Cosgrove, E. H. Eylar

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7 Scopus citations


Studies in 13 normal subjects, 9 patients with multiple sclerosis (MS) within 3 wk of exacerbation and 16 others 1 to 6 mth after onset were carried out for evidence of cell mediated hypersensitivity to myelin basic protein. Ten patients with stroke and 10 with Guillain Barre syndrome were studied as additional controls. Peripheral leukocytes obtained by leukapheresis were packed into capillary tubes and allowed to migrate out onto glass in the presence or absence of myelin basic protein. Cells of patients within 3 wk of an MS episode gave a mean migration index of 68 ± 9%, and those 1 to 6 mth after onset, 93 ± 21%. For the entire MS group the mean index was 88 ± 20%; for those with Guillain Barre, 103 ± 7%; and for the stroke patients, 107 ± 11%. Results for the acutely ill MS patients were significant (P < 0.005). The data are similar to those obtained using the migration inhibition factor assay but show that sensitized lymphocytes also elaborate a second mediator during acute exacerbations of illness. These observations strengthen evidence that sensitization to this potent encephalitogen occurs simultaneously with exacerbations of clinical illness.

Original languageEnglish (US)
Pages (from-to)985-988
Number of pages4
JournalCanadian Medical Association Journal
Issue number9
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • Medicine(all)


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