DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS

A. Gomez-Pan; M. Albinus; J. D. Reed; B. Shaw; R. Hall; G. M. Besser; D. H. Coy; A. J. Kastin; A. V. Schally

doi:10.1016/S0140-6736(75)91686-4

DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS

A. Gomez-Pan, M. Albinus, J. D. Reed, B. Shaw, R. Hall, G. M. Besser, D. H. Coy, A. J. Kastin, A. V. Schally

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124 Scopus citations

Abstract

Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.- R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.

Original language	English (US)
Pages (from-to)	888-890
Number of pages	3
Journal	The Lancet
Volume	305
Issue number	7912
DOIs	https://doi.org/10.1016/S0140-6736(75)91686-4
State	Published - Apr 19 1975
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Gomez-Pan, A., Albinus, M., Reed, J. D., Shaw, B., Hall, R., Besser, G. M., Coy, D. H., Kastin, A. J., & Schally, A. V. (1975). DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS. The Lancet, 305(7912), 888-890. https://doi.org/10.1016/S0140-6736(75)91686-4

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title = "DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS",

abstract = "Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.- R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.",

author = "A. Gomez-Pan and M. Albinus and Reed, {J. D.} and B. Shaw and R. Hall and Besser, {G. M.} and Coy, {D. H.} and Kastin, {A. J.} and Schally, {A. V.}",

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AU - Gomez-Pan, A.

AU - Albinus, M.

AU - Reed, J. D.

AU - Shaw, B.

AU - Hall, R.

AU - Besser, G. M.

AU - Coy, D. H.

AU - Kastin, A. J.

AU - Schally, A. V.

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AB - Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.- R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.

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