DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS

A. Gomez-Pan; M. Albinus; J. D. Reed; B. Shaw; R. Hall; G. M. Besser; D. H. Coy; A. J. Kastin; A. V. Schally

doi:10.1016/S0140-6736(75)91686-4

DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS

A. Gomez-Pan, M. Albinus, J. D. Reed, B. Shaw, R. Hall, G. M. Besser, D. H. Coy, A. J. Kastin, A. V. Schally

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Abstract

Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.- R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.

Original language	English (US)
Pages (from-to)	888-890
Number of pages	3
Journal	The Lancet
Volume	305
Issue number	7912
DOIs	https://doi.org/10.1016/S0140-6736(75)91686-4
State	Published - Apr 19 1975
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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@article{295dd98319d84c6095930c3c08406f8e,

title = "DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS",

abstract = "Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.- R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.",

author = "A. Gomez-Pan and M. Albinus and Reed, {J. D.} and B. Shaw and R. Hall and Besser, {G. M.} and Coy, {D. H.} and Kastin, {A. J.} and Schally, {A. V.}",

note = "Funding Information: supported by the Scientific Research Committee of the New- castle Health Authority (Teaching). Requests for reprints should be addressed Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1975",

month = apr,

day = "19",

doi = "10.1016/S0140-6736(75)91686-4",

language = "English (US)",

volume = "305",

pages = "888--890",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "7912",

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TY - JOUR

T1 - DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS

AU - Gomez-Pan, A.

AU - Albinus, M.

AU - Reed, J. D.

AU - Shaw, B.

AU - Hall, R.

AU - Besser, G. M.

AU - Coy, D. H.

AU - Kastin, A. J.

AU - Schally, A. V.

N1 - Funding Information: supported by the Scientific Research Committee of the New- castle Health Authority (Teaching). Requests for reprints should be addressed Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1975/4/19

Y1 - 1975/4/19

N2 - Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.- R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.

AB - Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.- R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.

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U2 - 10.1016/S0140-6736(75)91686-4

DO - 10.1016/S0140-6736(75)91686-4

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AN - SCOPUS:0016856744

VL - 305

SP - 888

EP - 890

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 7912

ER -

DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS

Abstract

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