DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS

A. Gomez-Pan, M. Albinus, J. D. Reed, B. Shaw, R. Hall, G. M. Besser, D. H. Coy, A. J. Kastin, A. V. Schally

Research output: Contribution to journalArticle

124 Scopus citations

Abstract

Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.- R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.

Original languageEnglish (US)
Pages (from-to)888-890
Number of pages3
JournalThe Lancet
Volume305
Issue number7912
DOIs
StatePublished - Apr 19 1975
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Gomez-Pan, A., Albinus, M., Reed, J. D., Shaw, B., Hall, R., Besser, G. M., Coy, D. H., Kastin, A. J., & Schally, A. V. (1975). DIRECT INHIBITION OF GASTRIC ACID AND PEPSIN SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN CATS. The Lancet, 305(7912), 888-890. https://doi.org/10.1016/S0140-6736(75)91686-4