Abstract
Growth-hormone release-inhibiting hormone (G.H.-R.I.H.) inhibited gastric acid and pepsin secretion in response to pentagastrin and food stimulation in cats. This effect is mediated by a direct action on the parietal and peptic cells. No evidence of a post-inhibitory acid or pepsin secretory rebound was obtained. Thus a compound of hypothalamic origin can exert a direct effect on exocrine secretion. In view of its widespread actions and its presence in relatively high concentrations in various organs apart from the hypothalamus, G.H.- R.I.H. might also be regarded as a factor responsible for local coordination of endocrine and exocrine secretion.
Original language | English (US) |
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Pages (from-to) | 888-890 |
Number of pages | 3 |
Journal | The Lancet |
Volume | 305 |
Issue number | 7912 |
DOIs | |
State | Published - Apr 19 1975 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)