Direct chromosomal analysis of human spermatozoa: Preliminary results from 18 normal men

R. H. Martin, C. C. Lin, W. Balkan, K. Burns

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Chromosomal analysis of 240 spermatozoa from 18 normal men was performed using in vitro fertilization of zona-free golden hamster eggs. The frequency of chromosome abnormalities in this population was 9.2% (22/240). Of the abnormal complements, 18 were aneuploid (13 hyperploid and five hypoploid) and four had a chromosome break. The sex ratio of Y-bearing to X-bearing sperm was .68. The frequency and type of sperm chromosome abnormalities is compared with those seen in spontaneous abortions.

Original languageEnglish (US)
Pages (from-to)459-468
Number of pages10
JournalAmerican journal of human genetics
Volume34
Issue number3
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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