Diode laser surgery: Ab interno and ab externo versus conventional surgery in rabbits

Carol Karp, E. J. Higginbotham, D. P. Edward, D. C. Musch

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Fibroblastic proliferation of subconjunctival tissues remains a primary mechanism of failure in filtration surgery. Minimizing the surgical manipulation of episcleral tissues may reduce scarring. Laser sclerostomy surgery involves minimal tissue dissection, and is gaining attention as a method of potentially improving filter duration in high-risk cases. Methods: Twenty-five New Zealand rabbits underwent filtration surgery in one eye, and the fellow eye remained as the unoperated control. Ten rabbits underwent ab externo diode laser sclerostomy surgery, ten underwent ab interno diode sclerostomy surgery, and five had posterior sclerostomy procedures. Filtration failure was defined as a less-than-4-mmHg intraocular pressure (IOP) difference between the operative and control eyes. Results: The mean time to failure for the ab externo, ab interno, and conventional posterior sclerostomy techniques measured 17.4 ± 11.5, 13.1 ± 6.7, and 6.0 ± 3.1 days, respectively. In a comparison of the laser-treated groups with the conventional procedure, the time to failure was significantly longer (P = 0.02) for the ab externo filter. The mean ab interno sclerostomy duration was longer than the posterior lip procedure, but this difference was not statistically significant (P = 0.15). The overall level of IOP reduction was similar in the three groups. Conclusions: These data suggest that diode laser sclerostomy is a feasible technique in rabbits, and the ab externo approach resulted in longer filter duration than the conventional posterior lip procedure in this model.

Original languageEnglish
Pages (from-to)1567-1573
Number of pages7
JournalOphthalmology
Volume100
Issue number10
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Sclerostomy
Semiconductor Lasers
Laser Therapy
Rabbits
Filtering Surgery
Lip
Intraocular Pressure
Cicatrix
Dissection
Lasers

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Karp, C., Higginbotham, E. J., Edward, D. P., & Musch, D. C. (1993). Diode laser surgery: Ab interno and ab externo versus conventional surgery in rabbits. Ophthalmology, 100(10), 1567-1573.

Diode laser surgery : Ab interno and ab externo versus conventional surgery in rabbits. / Karp, Carol; Higginbotham, E. J.; Edward, D. P.; Musch, D. C.

In: Ophthalmology, Vol. 100, No. 10, 01.01.1993, p. 1567-1573.

Research output: Contribution to journalArticle

Karp, C, Higginbotham, EJ, Edward, DP & Musch, DC 1993, 'Diode laser surgery: Ab interno and ab externo versus conventional surgery in rabbits', Ophthalmology, vol. 100, no. 10, pp. 1567-1573.
Karp C, Higginbotham EJ, Edward DP, Musch DC. Diode laser surgery: Ab interno and ab externo versus conventional surgery in rabbits. Ophthalmology. 1993 Jan 1;100(10):1567-1573.
Karp, Carol ; Higginbotham, E. J. ; Edward, D. P. ; Musch, D. C. / Diode laser surgery : Ab interno and ab externo versus conventional surgery in rabbits. In: Ophthalmology. 1993 ; Vol. 100, No. 10. pp. 1567-1573.
@article{e8ef8b00314b4e8e8bd62b2e66963989,
title = "Diode laser surgery: Ab interno and ab externo versus conventional surgery in rabbits",
abstract = "Background: Fibroblastic proliferation of subconjunctival tissues remains a primary mechanism of failure in filtration surgery. Minimizing the surgical manipulation of episcleral tissues may reduce scarring. Laser sclerostomy surgery involves minimal tissue dissection, and is gaining attention as a method of potentially improving filter duration in high-risk cases. Methods: Twenty-five New Zealand rabbits underwent filtration surgery in one eye, and the fellow eye remained as the unoperated control. Ten rabbits underwent ab externo diode laser sclerostomy surgery, ten underwent ab interno diode sclerostomy surgery, and five had posterior sclerostomy procedures. Filtration failure was defined as a less-than-4-mmHg intraocular pressure (IOP) difference between the operative and control eyes. Results: The mean time to failure for the ab externo, ab interno, and conventional posterior sclerostomy techniques measured 17.4 ± 11.5, 13.1 ± 6.7, and 6.0 ± 3.1 days, respectively. In a comparison of the laser-treated groups with the conventional procedure, the time to failure was significantly longer (P = 0.02) for the ab externo filter. The mean ab interno sclerostomy duration was longer than the posterior lip procedure, but this difference was not statistically significant (P = 0.15). The overall level of IOP reduction was similar in the three groups. Conclusions: These data suggest that diode laser sclerostomy is a feasible technique in rabbits, and the ab externo approach resulted in longer filter duration than the conventional posterior lip procedure in this model.",
author = "Carol Karp and Higginbotham, {E. J.} and Edward, {D. P.} and Musch, {D. C.}",
year = "1993",
month = "1",
day = "1",
language = "English",
volume = "100",
pages = "1567--1573",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - Diode laser surgery

T2 - Ab interno and ab externo versus conventional surgery in rabbits

AU - Karp, Carol

AU - Higginbotham, E. J.

AU - Edward, D. P.

AU - Musch, D. C.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Background: Fibroblastic proliferation of subconjunctival tissues remains a primary mechanism of failure in filtration surgery. Minimizing the surgical manipulation of episcleral tissues may reduce scarring. Laser sclerostomy surgery involves minimal tissue dissection, and is gaining attention as a method of potentially improving filter duration in high-risk cases. Methods: Twenty-five New Zealand rabbits underwent filtration surgery in one eye, and the fellow eye remained as the unoperated control. Ten rabbits underwent ab externo diode laser sclerostomy surgery, ten underwent ab interno diode sclerostomy surgery, and five had posterior sclerostomy procedures. Filtration failure was defined as a less-than-4-mmHg intraocular pressure (IOP) difference between the operative and control eyes. Results: The mean time to failure for the ab externo, ab interno, and conventional posterior sclerostomy techniques measured 17.4 ± 11.5, 13.1 ± 6.7, and 6.0 ± 3.1 days, respectively. In a comparison of the laser-treated groups with the conventional procedure, the time to failure was significantly longer (P = 0.02) for the ab externo filter. The mean ab interno sclerostomy duration was longer than the posterior lip procedure, but this difference was not statistically significant (P = 0.15). The overall level of IOP reduction was similar in the three groups. Conclusions: These data suggest that diode laser sclerostomy is a feasible technique in rabbits, and the ab externo approach resulted in longer filter duration than the conventional posterior lip procedure in this model.

AB - Background: Fibroblastic proliferation of subconjunctival tissues remains a primary mechanism of failure in filtration surgery. Minimizing the surgical manipulation of episcleral tissues may reduce scarring. Laser sclerostomy surgery involves minimal tissue dissection, and is gaining attention as a method of potentially improving filter duration in high-risk cases. Methods: Twenty-five New Zealand rabbits underwent filtration surgery in one eye, and the fellow eye remained as the unoperated control. Ten rabbits underwent ab externo diode laser sclerostomy surgery, ten underwent ab interno diode sclerostomy surgery, and five had posterior sclerostomy procedures. Filtration failure was defined as a less-than-4-mmHg intraocular pressure (IOP) difference between the operative and control eyes. Results: The mean time to failure for the ab externo, ab interno, and conventional posterior sclerostomy techniques measured 17.4 ± 11.5, 13.1 ± 6.7, and 6.0 ± 3.1 days, respectively. In a comparison of the laser-treated groups with the conventional procedure, the time to failure was significantly longer (P = 0.02) for the ab externo filter. The mean ab interno sclerostomy duration was longer than the posterior lip procedure, but this difference was not statistically significant (P = 0.15). The overall level of IOP reduction was similar in the three groups. Conclusions: These data suggest that diode laser sclerostomy is a feasible technique in rabbits, and the ab externo approach resulted in longer filter duration than the conventional posterior lip procedure in this model.

UR - http://www.scopus.com/inward/record.url?scp=0027371245&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027371245&partnerID=8YFLogxK

M3 - Article

C2 - 8414417

AN - SCOPUS:0027371245

VL - 100

SP - 1567

EP - 1573

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 10

ER -