Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging

S. H. Lisanby, W. M. McDonald, E. W. Massey, P. M. Doraiswamy, M. Rozear, O. B. Boyko, K. R R Krishnan, Charles Nemeroff

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Parkinson's disease (PD) is associated with changes in the substantia nigra, which communicates with subcortical nuclei. This study investigates subcortical nuclei volume in PD in vivo by magnetic resonance (MR) imaging. Caudate, putaminal, and thalamic nuclei were measured on axial MR images using a point counting method and systematic sampling. PD patients (n = 21) had significantly smaller subcortical nuclei than age- and sex-matched controls (p < 0.001) and depressed patients (p < 0.01). The decline in PD was not correlated with age, sex, or cortical volume. Depressed patients had significantly smaller caudate and putaminal nuclei than controls (p < 0.05 and 0.01, respectively) but thalamic nuclei were not significantly different. Caudate, putaminal, and thalamic nuclei volumes of controls were significantly negatively correlated with age (r = -0.58, p < 0.01; r = - 0.77, p < 0.001; r = -0.57, p < 0.01, respectively). Depressed subjects demonstrated a negative trend. Volumetric measurements by MR imaging may be a useful in investigating the role of the basal ganglia in neurological disorders.

Original languageEnglish
Pages (from-to)13-21
Number of pages9
JournalJournal of Neural Transmission, Supplement
Issue number40
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Thalamic Nuclei
Parkinson Disease
Caudate Nucleus
Magnetic Resonance Imaging
Substantia Nigra
Basal Ganglia
Nervous System Diseases
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lisanby, S. H., McDonald, W. M., Massey, E. W., Doraiswamy, P. M., Rozear, M., Boyko, O. B., ... Nemeroff, C. (1993). Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging. Journal of Neural Transmission, Supplement, (40), 13-21.

Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging. / Lisanby, S. H.; McDonald, W. M.; Massey, E. W.; Doraiswamy, P. M.; Rozear, M.; Boyko, O. B.; Krishnan, K. R R; Nemeroff, Charles.

In: Journal of Neural Transmission, Supplement, No. 40, 01.01.1993, p. 13-21.

Research output: Contribution to journalArticle

Lisanby, SH, McDonald, WM, Massey, EW, Doraiswamy, PM, Rozear, M, Boyko, OB, Krishnan, KRR & Nemeroff, C 1993, 'Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging', Journal of Neural Transmission, Supplement, no. 40, pp. 13-21.
Lisanby SH, McDonald WM, Massey EW, Doraiswamy PM, Rozear M, Boyko OB et al. Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging. Journal of Neural Transmission, Supplement. 1993 Jan 1;(40):13-21.
Lisanby, S. H. ; McDonald, W. M. ; Massey, E. W. ; Doraiswamy, P. M. ; Rozear, M. ; Boyko, O. B. ; Krishnan, K. R R ; Nemeroff, Charles. / Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging. In: Journal of Neural Transmission, Supplement. 1993 ; No. 40. pp. 13-21.
@article{6e897259b39c4f84b2af68f8cb8df2b8,
title = "Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging",
abstract = "Parkinson's disease (PD) is associated with changes in the substantia nigra, which communicates with subcortical nuclei. This study investigates subcortical nuclei volume in PD in vivo by magnetic resonance (MR) imaging. Caudate, putaminal, and thalamic nuclei were measured on axial MR images using a point counting method and systematic sampling. PD patients (n = 21) had significantly smaller subcortical nuclei than age- and sex-matched controls (p < 0.001) and depressed patients (p < 0.01). The decline in PD was not correlated with age, sex, or cortical volume. Depressed patients had significantly smaller caudate and putaminal nuclei than controls (p < 0.05 and 0.01, respectively) but thalamic nuclei were not significantly different. Caudate, putaminal, and thalamic nuclei volumes of controls were significantly negatively correlated with age (r = -0.58, p < 0.01; r = - 0.77, p < 0.001; r = -0.57, p < 0.01, respectively). Depressed subjects demonstrated a negative trend. Volumetric measurements by MR imaging may be a useful in investigating the role of the basal ganglia in neurological disorders.",
author = "Lisanby, {S. H.} and McDonald, {W. M.} and Massey, {E. W.} and Doraiswamy, {P. M.} and M. Rozear and Boyko, {O. B.} and Krishnan, {K. R R} and Charles Nemeroff",
year = "1993",
month = "1",
day = "1",
language = "English",
pages = "13--21",
journal = "Journal of Neural Transmission, Supplement",
issn = "0303-6995",
publisher = "Springer Wien",
number = "40",

}

TY - JOUR

T1 - Diminished subcortical nuclei volumes in Parkinson's disease by MR imaging

AU - Lisanby, S. H.

AU - McDonald, W. M.

AU - Massey, E. W.

AU - Doraiswamy, P. M.

AU - Rozear, M.

AU - Boyko, O. B.

AU - Krishnan, K. R R

AU - Nemeroff, Charles

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Parkinson's disease (PD) is associated with changes in the substantia nigra, which communicates with subcortical nuclei. This study investigates subcortical nuclei volume in PD in vivo by magnetic resonance (MR) imaging. Caudate, putaminal, and thalamic nuclei were measured on axial MR images using a point counting method and systematic sampling. PD patients (n = 21) had significantly smaller subcortical nuclei than age- and sex-matched controls (p < 0.001) and depressed patients (p < 0.01). The decline in PD was not correlated with age, sex, or cortical volume. Depressed patients had significantly smaller caudate and putaminal nuclei than controls (p < 0.05 and 0.01, respectively) but thalamic nuclei were not significantly different. Caudate, putaminal, and thalamic nuclei volumes of controls were significantly negatively correlated with age (r = -0.58, p < 0.01; r = - 0.77, p < 0.001; r = -0.57, p < 0.01, respectively). Depressed subjects demonstrated a negative trend. Volumetric measurements by MR imaging may be a useful in investigating the role of the basal ganglia in neurological disorders.

AB - Parkinson's disease (PD) is associated with changes in the substantia nigra, which communicates with subcortical nuclei. This study investigates subcortical nuclei volume in PD in vivo by magnetic resonance (MR) imaging. Caudate, putaminal, and thalamic nuclei were measured on axial MR images using a point counting method and systematic sampling. PD patients (n = 21) had significantly smaller subcortical nuclei than age- and sex-matched controls (p < 0.001) and depressed patients (p < 0.01). The decline in PD was not correlated with age, sex, or cortical volume. Depressed patients had significantly smaller caudate and putaminal nuclei than controls (p < 0.05 and 0.01, respectively) but thalamic nuclei were not significantly different. Caudate, putaminal, and thalamic nuclei volumes of controls were significantly negatively correlated with age (r = -0.58, p < 0.01; r = - 0.77, p < 0.001; r = -0.57, p < 0.01, respectively). Depressed subjects demonstrated a negative trend. Volumetric measurements by MR imaging may be a useful in investigating the role of the basal ganglia in neurological disorders.

UR - http://www.scopus.com/inward/record.url?scp=0027329922&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027329922&partnerID=8YFLogxK

M3 - Article

C2 - 8294897

AN - SCOPUS:0027329922

SP - 13

EP - 21

JO - Journal of Neural Transmission, Supplement

JF - Journal of Neural Transmission, Supplement

SN - 0303-6995

IS - 40

ER -