Dimethylheptyl-THC-11 OIC acid: A nonpsychoactive antiinflammatory agent with a cannabinoid template structure

Robert B. Zurier, Ronald G. Rossetti, Joan H. Lane, John M. Goldberg, Sheila A. Hunter, Sumner H. Burstein

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Objective. To assess the antiinflammatory activity of dimethylheptyl- THC-11 oic acid (DMH-11C), a non-psychoactive synthetic derivative of tetrahydrocannabinol. Methods. Acute inflammation was induced by injection of interleukin-1β and tumor necrosis factor α into subcutaneous air pouches formed on the backs of mice. Inflammation was quantified 6 hours later by pouch fluid leukocyte counts. Adjuvant-induced polyarthritis in rats was used as a model of chronic inflammation and joint tissue injury. Animals were either untreated, treated with safflower oil, or treated with DMH-11C in safflower oil. Arthritis was assessed by clinical observation and by histomorphologic evaluation of tibiotarsal joints. Results. Oral administration of DMH-11C reduced the accumulation of pouch fluid leukocytes and significantly reduced the severity of adjuvant-induced polyarthritis. Histopathologic studies of tibiotarsal joints showed that DMH-11C treatment attenuated pannus formation and joint tissue injury. Conclusion. DMH-11C suppresses acute inflammation in the subcutaneous air pouch in mice and chronic joint inflammation characteristic of adjuvant disease in rats. These results demonstrate the potential use of this nonpsychoactive cannabinoid as an anti-inflammatory agent.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalArthritis and Rheumatism
Volume41
Issue number1
DOIs
StatePublished - Jan 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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