Diltiazem and contraction in cat ventricular muscle during experimentally induced right ventricular systolic hypertension

S. S. Wong, R. J. Myerburg, A. M. Ezrin, W. S. Fitterman, A. L. Bassett

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The effects of diltiazem (2.2 x 10-7 and 2.2 x 10-6 N) on isometric contraction and K+-induced contracture (Pc) were determined for right ventricular muscles from normal cats and cats with right ventricular systolic hypertension (RVSH) monitored 4-15 days after partial pulmonary artery obstruction Muscles obtained from cats with RVSH had significantly decreased maximum isometric force (Po) and maximum rate of force development (dF/dt). Diltiazem (2.2 x 10-7 and 2.2 x 10-6 M) significantly reduced Pc of both normal and pressure-overloaded muscle. Po of normal muscle was decreased only by 2.2 x 10-6 M, while Po of pressure-overloaded muscle was significantly reduced at a lower concentration (2.2 x 10-7 M). The effect of diltiazem was reversed by ↑ [Ca2+]0. These results demonstrate that contractile function of pressure-overloaded ventricular myocardium is more sensitive to diltiazem.

Original languageEnglish (US)
Pages (from-to)76-84
Number of pages9
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume256
Issue number1
StatePublished - Jun 4 1982

ASJC Scopus subject areas

  • Pharmacology

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