Diltiazem and contraction in cat ventricular muscle during experimentally induced right ventricular systolic hypertension

S. S. Wong, Robert J Myerburg, A. M. Ezrin, W. S. Fitterman, A. L. Bassett

Research output: Contribution to journalArticle

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Abstract

The effects of diltiazem (2.2 x 10-7 and 2.2 x 10-6 N) on isometric contraction and K+-induced contracture (Pc) were determined for right ventricular muscles from normal cats and cats with right ventricular systolic hypertension (RVSH) monitored 4-15 days after partial pulmonary artery obstruction Muscles obtained from cats with RVSH had significantly decreased maximum isometric force (Po) and maximum rate of force development (dF/dt). Diltiazem (2.2 x 10-7 and 2.2 x 10-6 M) significantly reduced Pc of both normal and pressure-overloaded muscle. Po of normal muscle was decreased only by 2.2 x 10-6 M, while Po of pressure-overloaded muscle was significantly reduced at a lower concentration (2.2 x 10-7 M). The effect of diltiazem was reversed by ↑ [Ca2+]0. These results demonstrate that contractile function of pressure-overloaded ventricular myocardium is more sensitive to diltiazem.

Original languageEnglish
Pages (from-to)76-84
Number of pages9
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume256
Issue number1
StatePublished - Jun 4 1982

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Diltiazem
Cats
Hypertension
Muscles
Pressure
Isometric Contraction
Contracture
Ventricular Pressure
Pulmonary Artery
Myocardium

ASJC Scopus subject areas

  • Pharmacology

Cite this

Diltiazem and contraction in cat ventricular muscle during experimentally induced right ventricular systolic hypertension. / Wong, S. S.; Myerburg, Robert J; Ezrin, A. M.; Fitterman, W. S.; Bassett, A. L.

In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 256, No. 1, 04.06.1982, p. 76-84.

Research output: Contribution to journalArticle

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