Dilation of the aortic root in children infected with human immunodeficiency virus type 1

The prospective P 2C 2 HIV multicenter study

Wyman W. Lai, Steven D. Colan, Kirk A. Easley, Steven E Lipshultz, Thomas J. Starc, J. Timothy Bricker, Samuel Kaplan

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Vascular lesions have become more evident in human immunodeficiency virus type 1 (HIV)-infected patients as the result of earlier diagnosis, improved treatment, and longer survival. Aortic root dilation in HIV-infected children has not previously been described. This study was undertaken to determine the prevalence of aortic root dilation in HIV-infected children and to evaluate some of the potential pathogenic mechanisms. Methods: Aortic root measurements were incorporated into the routine echocardiographic surveillance of 280 children of HIV-infected women: an older cohort of 86 HIV-infected children and a neonatal cohort of 50 HIV-infected and 144 HIV-uninfected children. Results: By repeated-measures analyses, mean aortic root measurements were significantly increased in HIV-infected children versus HIV-uninfected children (P values of ≤.04 and ≤.005 at 2 and 5 years of age, respectively, for aortic annulus diameter, sinuses of Valsalva, and sinotubular junction): Heart rate, systolic blood pressure, stroke volume, hemoglobin, and hematocrit were not significantly associated with aortic root size. Left ventricular dilation, increased serum HIV RNA levels, and lower CD4 cell count measurements were associated with aortic root dilation at baseline. Conclusions: Mild and nonprogressive aortic root dilation was seen in children with vertically transmitted HIV infection from 2 to 9 years of age. Aortic root size was not significantly associated with markers for stress-modulated growth; however, aortic root dilation was associated with left ventricular dilation, increased viral load, and lower CD4 cell count in HIV-infected children. As prolonged survival of HIV-infected patients becomes more prevalent, some patients may require long-term follow-up of aortic root size.

Original languageEnglish
Pages (from-to)661-670
Number of pages10
JournalAmerican Heart Journal
Volume141
Issue number4
DOIs
StatePublished - Apr 12 2001
Externally publishedYes

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Multicenter Studies
HIV-1
Dilatation
CD4 Lymphocyte Count
Blood Pressure
Sinus of Valsalva
Survival
Virus Diseases
Viral Load
Hematocrit
Stroke Volume
Blood Vessels
Early Diagnosis
Hemoglobins
Heart Rate
RNA

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lai, W. W., Colan, S. D., Easley, K. A., Lipshultz, S. E., Starc, T. J., Bricker, J. T., & Kaplan, S. (2001). Dilation of the aortic root in children infected with human immunodeficiency virus type 1: The prospective P 2C 2 HIV multicenter study. American Heart Journal, 141(4), 661-670. https://doi.org/10.1067/mhj.2001.113757

Dilation of the aortic root in children infected with human immunodeficiency virus type 1 : The prospective P 2C 2 HIV multicenter study. / Lai, Wyman W.; Colan, Steven D.; Easley, Kirk A.; Lipshultz, Steven E; Starc, Thomas J.; Bricker, J. Timothy; Kaplan, Samuel.

In: American Heart Journal, Vol. 141, No. 4, 12.04.2001, p. 661-670.

Research output: Contribution to journalArticle

Lai, Wyman W. ; Colan, Steven D. ; Easley, Kirk A. ; Lipshultz, Steven E ; Starc, Thomas J. ; Bricker, J. Timothy ; Kaplan, Samuel. / Dilation of the aortic root in children infected with human immunodeficiency virus type 1 : The prospective P 2C 2 HIV multicenter study. In: American Heart Journal. 2001 ; Vol. 141, No. 4. pp. 661-670.
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