Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology

Laura Barisoni-Thomas, Charlotte Gimpel, Renate Kain, Arvydas Laurinavicius, Gloria Bueno, Caihong Zeng, Zhihong Liu, Franz Schaefer, Matthias Kretzler, Lawrence B. Holzman, Stephen M. Hewitt

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

The introduction of digital pathology to nephrology provides a platform for the development of new methodologies and protocols for visual, morphometric and computer-aided assessment of renal biopsies. Application of digital imaging to pathology made substantial progress over the past decade; it is now in use for education, clinical trials and translational research. Digital pathology evolved as a valuable tool to generate comprehensive structural information in digital form, a key prerequisite for achieving precision pathology for computational biology. The application of this new technology on an international scale is driving novel methods for collaborations, providing unique opportunities but also challenges. Standardization of methods needs to be rigorously evaluated and applied at each step, from specimen processing to scanning, uploading into digital repositories, morphologic, morphometric and computer-aided assessment, data collection and analysis. In this review, we discuss the status and opportunities created by the application of digital imaging to precision nephropathology, and present a vision for the near future.

Original languageEnglish (US)
Pages (from-to)176-187
Number of pages12
JournalClinical Kidney Journal
Volume10
Issue number2
DOIs
StatePublished - 2017

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Internationality
Pathology
Translational Medical Research
Nephrology
Computational Biology
Clinical Trials
Technology
Kidney
Biopsy
Education

Keywords

  • Glomerulosclerosis
  • Kidney biopsy
  • Minimal change disease
  • Nephrotic syndrome
  • Proteinuria

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology. / Barisoni-Thomas, Laura; Gimpel, Charlotte; Kain, Renate; Laurinavicius, Arvydas; Bueno, Gloria; Zeng, Caihong; Liu, Zhihong; Schaefer, Franz; Kretzler, Matthias; Holzman, Lawrence B.; Hewitt, Stephen M.

In: Clinical Kidney Journal, Vol. 10, No. 2, 2017, p. 176-187.

Research output: Contribution to journalReview article

Barisoni-Thomas, L, Gimpel, C, Kain, R, Laurinavicius, A, Bueno, G, Zeng, C, Liu, Z, Schaefer, F, Kretzler, M, Holzman, LB & Hewitt, SM 2017, 'Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology', Clinical Kidney Journal, vol. 10, no. 2, pp. 176-187. https://doi.org/10.1093/ckj/sfw129
Barisoni-Thomas, Laura ; Gimpel, Charlotte ; Kain, Renate ; Laurinavicius, Arvydas ; Bueno, Gloria ; Zeng, Caihong ; Liu, Zhihong ; Schaefer, Franz ; Kretzler, Matthias ; Holzman, Lawrence B. ; Hewitt, Stephen M. / Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology. In: Clinical Kidney Journal. 2017 ; Vol. 10, No. 2. pp. 176-187.
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