Abstract
The introduction of digital pathology to nephrology provides a platform for the development of new methodologies and protocols for visual, morphometric and computer-aided assessment of renal biopsies. Application of digital imaging to pathology made substantial progress over the past decade; it is now in use for education, clinical trials and translational research. Digital pathology evolved as a valuable tool to generate comprehensive structural information in digital form, a key prerequisite for achieving precision pathology for computational biology. The application of this new technology on an international scale is driving novel methods for collaborations, providing unique opportunities but also challenges. Standardization of methods needs to be rigorously evaluated and applied at each step, from specimen processing to scanning, uploading into digital repositories, morphologic, morphometric and computer-aided assessment, data collection and analysis. In this review, we discuss the status and opportunities created by the application of digital imaging to precision nephropathology, and present a vision for the near future.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 176-187 |
| Number of pages | 12 |
| Journal | Clinical Kidney Journal |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2017 |
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Keywords
- Glomerulosclerosis
- Kidney biopsy
- Minimal change disease
- Nephrotic syndrome
- Proteinuria
ASJC Scopus subject areas
- Nephrology
- Transplantation
Cite this
Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology. / Barisoni-Thomas, Laura; Gimpel, Charlotte; Kain, Renate; Laurinavicius, Arvydas; Bueno, Gloria; Zeng, Caihong; Liu, Zhihong; Schaefer, Franz; Kretzler, Matthias; Holzman, Lawrence B.; Hewitt, Stephen M.
In: Clinical Kidney Journal, Vol. 10, No. 2, 2017, p. 176-187.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology
AU - Barisoni-Thomas, Laura
AU - Gimpel, Charlotte
AU - Kain, Renate
AU - Laurinavicius, Arvydas
AU - Bueno, Gloria
AU - Zeng, Caihong
AU - Liu, Zhihong
AU - Schaefer, Franz
AU - Kretzler, Matthias
AU - Holzman, Lawrence B.
AU - Hewitt, Stephen M.
PY - 2017
Y1 - 2017
N2 - The introduction of digital pathology to nephrology provides a platform for the development of new methodologies and protocols for visual, morphometric and computer-aided assessment of renal biopsies. Application of digital imaging to pathology made substantial progress over the past decade; it is now in use for education, clinical trials and translational research. Digital pathology evolved as a valuable tool to generate comprehensive structural information in digital form, a key prerequisite for achieving precision pathology for computational biology. The application of this new technology on an international scale is driving novel methods for collaborations, providing unique opportunities but also challenges. Standardization of methods needs to be rigorously evaluated and applied at each step, from specimen processing to scanning, uploading into digital repositories, morphologic, morphometric and computer-aided assessment, data collection and analysis. In this review, we discuss the status and opportunities created by the application of digital imaging to precision nephropathology, and present a vision for the near future.
AB - The introduction of digital pathology to nephrology provides a platform for the development of new methodologies and protocols for visual, morphometric and computer-aided assessment of renal biopsies. Application of digital imaging to pathology made substantial progress over the past decade; it is now in use for education, clinical trials and translational research. Digital pathology evolved as a valuable tool to generate comprehensive structural information in digital form, a key prerequisite for achieving precision pathology for computational biology. The application of this new technology on an international scale is driving novel methods for collaborations, providing unique opportunities but also challenges. Standardization of methods needs to be rigorously evaluated and applied at each step, from specimen processing to scanning, uploading into digital repositories, morphologic, morphometric and computer-aided assessment, data collection and analysis. In this review, we discuss the status and opportunities created by the application of digital imaging to precision nephropathology, and present a vision for the near future.
KW - Glomerulosclerosis
KW - Kidney biopsy
KW - Minimal change disease
KW - Nephrotic syndrome
KW - Proteinuria
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UR - http://www.scopus.com/inward/citedby.url?scp=85020117223&partnerID=8YFLogxK
U2 - 10.1093/ckj/sfw129
DO - 10.1093/ckj/sfw129
M3 - Review article
AN - SCOPUS:85020117223
VL - 10
SP - 176
EP - 187
JO - Clinical Kidney Journal
JF - Clinical Kidney Journal
SN - 2048-8505
IS - 2
ER -