@article{51d7a268d91648ba9894a40396536732,
title = "Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology",
abstract = "The introduction of digital pathology to nephrology provides a platform for the development of new methodologies and protocols for visual, morphometric and computer-aided assessment of renal biopsies. Application of digital imaging to pathology made substantial progress over the past decade; it is now in use for education, clinical trials and translational research. Digital pathology evolved as a valuable tool to generate comprehensive structural information in digital form, a key prerequisite for achieving precision pathology for computational biology. The application of this new technology on an international scale is driving novel methods for collaborations, providing unique opportunities but also challenges. Standardization of methods needs to be rigorously evaluated and applied at each step, from specimen processing to scanning, uploading into digital repositories, morphologic, morphometric and computer-aided assessment, data collection and analysis. In this review, we discuss the status and opportunities created by the application of digital imaging to precision nephropathology, and present a vision for the near future.",
keywords = "Glomerulosclerosis, Kidney biopsy, Minimal change disease, Nephrotic syndrome, Proteinuria",
author = "Laura Barisoni and Charlotte Gimpel and Renate Kain and Arvydas Laurinavicius and Gloria Bueno and Caihong Zeng and Zhihong Liu and Franz Schaefer and Matthias Kretzler and Holzman, {Lawrence B.} and Hewitt, {Stephen M.}",
note = "Funding Information: The authors acknowledge financial support from (i) the EC Marie Curie Actions, AIDPATH project (no. 612471); (ii) the Nephrotic Syndrome Study Network Consortium (NEPTUNE), part of the National Center for Advancing Translational Sciences (NCATS), the Rare Disease Clinical Research Network (RDCRN), and supported through a collaboration between the Office of Rare Diseases Research (ORDR), NCATS and the National Institute of Diabetes, Digestive, and Kidney Diseases. RDCRN is an initiative of ORDR and NCATS. Additional funding and/or programmatic support for this project has also been provided by the University of Michigan, NephCure Kidney International and the Halperin Foundation. (iii) EURenOmics: this work has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 305608. (iv) China-DiKiP, part of the Clinical Research Program of Jiangsu Province (no. BL2012007), part of the National Key Technology RandD Program (no. 2013BAI09B04), part of NEPTUNE China. (v) The intramural program, Center for Cancer Research, National Cancer Institute, National Institutes of Health. The authors also wish to acknowledge the INTEGRATE group of investigators. NEPTUNE: Laura Barisoni, Serena Bagnasco, Carmen Avila-Casado, Jeffrey Hodgin, Joseph Gaut, Matthew Palmer, Virginie Royal, David Thomas, Avi Rosenberg, Matthias Kretzler, Jun Wu; EURenOmics: Charlotte Gimpel, Renate Kain, Virginie Royale, Ivana Simic, Shane Meehan, Sandrine Florquine, Marion Rabant, Franz Shaefer; China-DiKiP: Zhihong Liu, CaihongZeng Jianghua Chen, Heng Li Zhangsuo Liu, Guolan Xing Shengqiang Yu, Jun Wu, Qiaoling Zhou, Wenbin Tang Li Wang, Guisen Li; AIDPATH: Arvydas Laurinavicious and Gloria Bueno; and INTEGRATE advisory committee: Stephen Hewitt, Helen Liapis, Robert Colvin. Publisher Copyright: {\textcopyright} The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA.",
year = "2017",
month = apr,
day = "1",
doi = "10.1093/ckj/sfw129",
language = "English (US)",
volume = "10",
pages = "176--187",
journal = "Clinical Kidney Journal",
issn = "2048-8505",
publisher = "Oxford University Press",
number = "2",
}