Digestion under duress

Nutrient acquisition and metabolism during hypoxia in the Pacific hagfish

Carol Bucking, Chris N. Glover, Chris M. Wood

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Hagfish feed by immersing themselves in the body cavities of decaying animals. This ensures a rich nutrient source for absorption via the gills, skin, and gut, but it may also subject hagfish to reduced levels of dissolved oxygen and elevated levels of the products of biological degradation. This study investigated the impacts of hypoxia and ammonia on the assimilation and metabolism of selected nutrients (glycine, l-alanine, and glucose) in Pacific hagfish (Eptatretus stoutii). Throughout exposure to hypoxia, plasma glucose levels increased. This was not accompanied by an increase in gut glucose transport, which suggests mobilization of glucose from body glycogen stores. Hypoxia preexposure enhanced glycine absorption across the gut and the gill, although l-alanine uptake was unchanged in these tissues. A 24-h period of exposure to hypoxia in hagfish concurrently exposed to waterborne radio-labeled glycine led to a large (5.7-fold) increase in brain glycine accumulation. Preexposure to high levels of waterborne ammonia (10 mM) for 24 h had no impact on gut or skin glycine uptake. These results indicate that hagfish are adapted to maintain nutrient assimilation despite environmental stressors and that tissuespecific absorption of key nutrients such as glycine can even be enhanced in order to sustain critical functions during hypoxia.

Original languageEnglish
Pages (from-to)607-617
Number of pages11
JournalPhysiological and Biochemical Zoology
Volume84
Issue number6
DOIs
StatePublished - Nov 1 2011

Fingerprint

Hagfishes
Myxini
glycine (amino acid)
Metabolism
Glycine
Nutrients
hypoxia
Digestion
digestion
metabolism
nutrients
digestive system
Glucose
Food
glucose
Ammonia
skin (animal)
Alanine
alanine
assimilation (physiology)

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Physiology
  • Biochemistry

Cite this

Digestion under duress : Nutrient acquisition and metabolism during hypoxia in the Pacific hagfish. / Bucking, Carol; Glover, Chris N.; Wood, Chris M.

In: Physiological and Biochemical Zoology, Vol. 84, No. 6, 01.11.2011, p. 607-617.

Research output: Contribution to journalArticle

Bucking, Carol ; Glover, Chris N. ; Wood, Chris M. / Digestion under duress : Nutrient acquisition and metabolism during hypoxia in the Pacific hagfish. In: Physiological and Biochemical Zoology. 2011 ; Vol. 84, No. 6. pp. 607-617.
@article{6a00db26520541a286b60251fd21f871,
title = "Digestion under duress: Nutrient acquisition and metabolism during hypoxia in the Pacific hagfish",
abstract = "Hagfish feed by immersing themselves in the body cavities of decaying animals. This ensures a rich nutrient source for absorption via the gills, skin, and gut, but it may also subject hagfish to reduced levels of dissolved oxygen and elevated levels of the products of biological degradation. This study investigated the impacts of hypoxia and ammonia on the assimilation and metabolism of selected nutrients (glycine, l-alanine, and glucose) in Pacific hagfish (Eptatretus stoutii). Throughout exposure to hypoxia, plasma glucose levels increased. This was not accompanied by an increase in gut glucose transport, which suggests mobilization of glucose from body glycogen stores. Hypoxia preexposure enhanced glycine absorption across the gut and the gill, although l-alanine uptake was unchanged in these tissues. A 24-h period of exposure to hypoxia in hagfish concurrently exposed to waterborne radio-labeled glycine led to a large (5.7-fold) increase in brain glycine accumulation. Preexposure to high levels of waterborne ammonia (10 mM) for 24 h had no impact on gut or skin glycine uptake. These results indicate that hagfish are adapted to maintain nutrient assimilation despite environmental stressors and that tissuespecific absorption of key nutrients such as glycine can even be enhanced in order to sustain critical functions during hypoxia.",
author = "Carol Bucking and Glover, {Chris N.} and Wood, {Chris M.}",
year = "2011",
month = "11",
day = "1",
doi = "10.1086/662630",
language = "English",
volume = "84",
pages = "607--617",
journal = "Physiological and Biochemical Zoology",
issn = "1522-2152",
publisher = "University of Chicago",
number = "6",

}

TY - JOUR

T1 - Digestion under duress

T2 - Nutrient acquisition and metabolism during hypoxia in the Pacific hagfish

AU - Bucking, Carol

AU - Glover, Chris N.

AU - Wood, Chris M.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Hagfish feed by immersing themselves in the body cavities of decaying animals. This ensures a rich nutrient source for absorption via the gills, skin, and gut, but it may also subject hagfish to reduced levels of dissolved oxygen and elevated levels of the products of biological degradation. This study investigated the impacts of hypoxia and ammonia on the assimilation and metabolism of selected nutrients (glycine, l-alanine, and glucose) in Pacific hagfish (Eptatretus stoutii). Throughout exposure to hypoxia, plasma glucose levels increased. This was not accompanied by an increase in gut glucose transport, which suggests mobilization of glucose from body glycogen stores. Hypoxia preexposure enhanced glycine absorption across the gut and the gill, although l-alanine uptake was unchanged in these tissues. A 24-h period of exposure to hypoxia in hagfish concurrently exposed to waterborne radio-labeled glycine led to a large (5.7-fold) increase in brain glycine accumulation. Preexposure to high levels of waterborne ammonia (10 mM) for 24 h had no impact on gut or skin glycine uptake. These results indicate that hagfish are adapted to maintain nutrient assimilation despite environmental stressors and that tissuespecific absorption of key nutrients such as glycine can even be enhanced in order to sustain critical functions during hypoxia.

AB - Hagfish feed by immersing themselves in the body cavities of decaying animals. This ensures a rich nutrient source for absorption via the gills, skin, and gut, but it may also subject hagfish to reduced levels of dissolved oxygen and elevated levels of the products of biological degradation. This study investigated the impacts of hypoxia and ammonia on the assimilation and metabolism of selected nutrients (glycine, l-alanine, and glucose) in Pacific hagfish (Eptatretus stoutii). Throughout exposure to hypoxia, plasma glucose levels increased. This was not accompanied by an increase in gut glucose transport, which suggests mobilization of glucose from body glycogen stores. Hypoxia preexposure enhanced glycine absorption across the gut and the gill, although l-alanine uptake was unchanged in these tissues. A 24-h period of exposure to hypoxia in hagfish concurrently exposed to waterborne radio-labeled glycine led to a large (5.7-fold) increase in brain glycine accumulation. Preexposure to high levels of waterborne ammonia (10 mM) for 24 h had no impact on gut or skin glycine uptake. These results indicate that hagfish are adapted to maintain nutrient assimilation despite environmental stressors and that tissuespecific absorption of key nutrients such as glycine can even be enhanced in order to sustain critical functions during hypoxia.

UR - http://www.scopus.com/inward/record.url?scp=80055029810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80055029810&partnerID=8YFLogxK

U2 - 10.1086/662630

DO - 10.1086/662630

M3 - Article

VL - 84

SP - 607

EP - 617

JO - Physiological and Biochemical Zoology

JF - Physiological and Biochemical Zoology

SN - 1522-2152

IS - 6

ER -