Diffusion tensor imaging of basal ganglia and thalamus in amyotrophic lateral sclerosis

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

PURPOSE: To assess the involvement of basal ganglia and thalamus in patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI) method. METHODS: Fourteen definite-ALS patients and 12 age-matched controls underwent whole brain DTI on a 3T scanner. Mean-diffusivity (MD) and fractional anisotropy (FA) were obtained bilaterally from the basal ganglia and thalamus in the regions-of-interest (ROIs). RESULTS: The MD was significantly higher (P<.02) in basal ganglia and thalamus in patients with ALS compared with controls. Correspondingly, the FA was significantly lower (P<.02) in these structures, except in caudate (P=04) and putamen (P= 06) in patients compared with controls. There were mild to strong correlations (r= 3-7) between the DTI measures of basal ganglia and finger-tap, foot-tap, and lip-and-tongue movement rate. CONCLUSIONS: The increased MD in basal ganglia and thalamus and decreased FA in globus pallidus and thalamus are indicative of neuronal loss or dysfunction in these structures.

Original languageEnglish
Pages (from-to)368-374
Number of pages7
JournalJournal of Neuroimaging
Volume23
Issue number3
DOIs
StatePublished - Jul 1 2013

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Diffusion Tensor Imaging
Amyotrophic Lateral Sclerosis
Basal Ganglia
Thalamus
Anisotropy
Globus Pallidus
Putamen
Lip
Tongue
Fingers
Foot
Brain

Keywords

  • Amyotrophic lateral sclerosis
  • Basal ganglia
  • DTI
  • Extra-motor
  • Thalamus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Diffusion tensor imaging of basal ganglia and thalamus in amyotrophic lateral sclerosis. / Sharma, Khema R; Sheriff, Sulaiman; Maudsley, Andrew A; Govind, Varan.

In: Journal of Neuroimaging, Vol. 23, No. 3, 01.07.2013, p. 368-374.

Research output: Contribution to journalArticle

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