Diffuse Lewy body disease: Clinical, pathological, and neuropsychological review

Cheryl A. Luis; Wiley Mittenberg; Carlton S. Gass; Ranjan Duara

doi:10.1023/A:1021626420760

Diffuse Lewy body disease: Clinical, pathological, and neuropsychological review

Cheryl A. Luis, Wiley Mittenberg, Carlton S. Gass, Ranjan Duara

Medicine

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The pathophysiological etiologies and clinical presentations of neurodegenerative dementias have been found to be complex and heterogeneous. Recently, Lewy body inclusions have been identified as an etiological factor in 20-34% of autopsied dementia cases. The term diffuse Lewy body disease (DLBD) is generally accepted as the diagnostic term representative of this currently under-reported and under-recognized disease. This article reviews the literature on the clinical, pathological, and neuropsychological features of this disorder. Differential diagnostic issues are discussed as well as current pharmacological treatment. Nine confirmed cases of DLBD are presented to demonstrate the various features of this disorder. The diagnostic implications of neuropsychological examination results are discussed in relation to other common dementing neurologic diseases.

Original language	English (US)
Pages (from-to)	137-150
Number of pages	14
Journal	Neuropsychology Review
Volume	9
Issue number	3
DOIs	https://doi.org/10.1023/A:1021626420760
State	Published - 1999

Keywords

Dementia
Diffuse Lewy body disease
Lewy bodies
Neurodegenerative disease

ASJC Scopus subject areas

Neuroscience(all)
Clinical Psychology

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10.1023/A:1021626420760

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title = "Diffuse Lewy body disease: Clinical, pathological, and neuropsychological review",

abstract = "The pathophysiological etiologies and clinical presentations of neurodegenerative dementias have been found to be complex and heterogeneous. Recently, Lewy body inclusions have been identified as an etiological factor in 20-34% of autopsied dementia cases. The term diffuse Lewy body disease (DLBD) is generally accepted as the diagnostic term representative of this currently under-reported and under-recognized disease. This article reviews the literature on the clinical, pathological, and neuropsychological features of this disorder. Differential diagnostic issues are discussed as well as current pharmacological treatment. Nine confirmed cases of DLBD are presented to demonstrate the various features of this disorder. The diagnostic implications of neuropsychological examination results are discussed in relation to other common dementing neurologic diseases.",

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T1 - Diffuse Lewy body disease

T2 - Clinical, pathological, and neuropsychological review

AU - Luis, Cheryl A.

AU - Mittenberg, Wiley

AU - Gass, Carlton S.

AU - Duara, Ranjan

PY - 1999

Y1 - 1999

N2 - The pathophysiological etiologies and clinical presentations of neurodegenerative dementias have been found to be complex and heterogeneous. Recently, Lewy body inclusions have been identified as an etiological factor in 20-34% of autopsied dementia cases. The term diffuse Lewy body disease (DLBD) is generally accepted as the diagnostic term representative of this currently under-reported and under-recognized disease. This article reviews the literature on the clinical, pathological, and neuropsychological features of this disorder. Differential diagnostic issues are discussed as well as current pharmacological treatment. Nine confirmed cases of DLBD are presented to demonstrate the various features of this disorder. The diagnostic implications of neuropsychological examination results are discussed in relation to other common dementing neurologic diseases.

AB - The pathophysiological etiologies and clinical presentations of neurodegenerative dementias have been found to be complex and heterogeneous. Recently, Lewy body inclusions have been identified as an etiological factor in 20-34% of autopsied dementia cases. The term diffuse Lewy body disease (DLBD) is generally accepted as the diagnostic term representative of this currently under-reported and under-recognized disease. This article reviews the literature on the clinical, pathological, and neuropsychological features of this disorder. Differential diagnostic issues are discussed as well as current pharmacological treatment. Nine confirmed cases of DLBD are presented to demonstrate the various features of this disorder. The diagnostic implications of neuropsychological examination results are discussed in relation to other common dementing neurologic diseases.

KW - Dementia

KW - Diffuse Lewy body disease

KW - Lewy bodies

KW - Neurodegenerative disease

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Diffuse Lewy body disease: Clinical, pathological, and neuropsychological review

Abstract

Keywords

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