Diffuse large b-cell lymphoma involving the central nervous system

Gabriela Gualco, Lawrence M. Weiss, Glen N. Barber, Carlos E. Bacchi

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Lymphomas involving the central nervous system are recognized increasingly in immunocompetent as well as immunosuppressed individuals, and the majority of the cases are diffuse large B-cell lymphoma (DLBCL). The aim of this study was to compare the immunophenotype, clinicopathological features, and association with Epstein-Barr virus (EBV) of DLBCL of the central nervous system (CNS) in 3 different clinical situations: primary, in immunocompetent patients; "primary," in immunosuppressed patients; and in patients with secondary involvement by systemic lymphoma. The authors reviewed the clinicopathological features, morphology, immunophenotype (according to germinal-center B-cell-like and nongerminal B-cell-like subtypes), and association with EBV in 36 cases of DLBCL of the CNS, including 25 primary cases, 5 associated with immunosuppression, and 6 cases with secondary involvement. Survival was evaluated in 15 cases of primary CNS lymphomas. Of the 36 patients, 19 were male and 18 female. Only 2 cases of lymphomas were EBV-positive; both occurred in immunosuppressed patients. Separation into germinal-center and non-germinal center subtypes by an immunohistochemistry panel showed that 68% of primary, 80% of secondary, and 83% of the cases associated with immunosuppression were of non-germinal-center subtype, respectively. Patients with non-germinal-center immunophenotype showed significantly worse survival than those with CNS lymphomas of the germinal-center subtype.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalInternational Journal of Surgical Pathology
Issue number1
StatePublished - Feb 2011


  • central nervous system lymphoma
  • diffuse large B-cell lymphoma
  • EBV
  • human immunodeficiency virus
  • immunocompetent
  • immunocompromised
  • immunohistochemistry
  • primary central nervous system lymphoma
  • WHO classification

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery


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