DIFFUSE INTRAEPIDERMAL DEPOSITION OF IMMUNOREACTANTS ON DIRECT IMMUNOFLUORESCENCE: A CLUE TO THE EARLY DIAGNOSIS OF EPIDERMAL NECROLYSIS

THEODORE KING, THOMAS N. HELM, RAFAEL VALENZUELA, WILMA F. BERGFELD

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background. Toxic epidermal necrolysis is a distinctive disorder that is readily identified clinically and histologically in advanced cases. Early on, however, toxic epidermal necrolysis may be difficult to identify. Some consider fixed drug eruption a limited form of toxic epidermal necrolysis. Methods. Direct immunofluorescence was performed on biopsy material of erythematous skin lesions. Results. Diffuse deposition of immunoreactants in the midmalpighian layer was noted. This finding has not been encountered in other disorders studied in our immunopathology laboratory. Conclusions. Diffuse immunoreactant deposition in the mid-epidermis should suggest a diagnosis of epidermal necrolysis either from toxic epidermal necrolysis or fixed drug eruption. Additional cases will need to be assessed to document the usefulness of this pattern for prospective diagnosis.

Original languageEnglish (US)
Pages (from-to)634-636
Number of pages3
JournalInternational journal of dermatology
Volume33
Issue number9
DOIs
StatePublished - Sep 1994

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'DIFFUSE INTRAEPIDERMAL DEPOSITION OF IMMUNOREACTANTS ON DIRECT IMMUNOFLUORESCENCE: A CLUE TO THE EARLY DIAGNOSIS OF EPIDERMAL NECROLYSIS'. Together they form a unique fingerprint.

  • Cite this