Diffuse cerebral ischemia in the cat: III. Neuropathological sequelae of severe ischemia

Myron Ginsberg, D. I. Graham, F. A. Welsh, W. W. Budd

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The neuropathological consequences of severe diffuse cerebral ischemia were investigated in an animal model in which postischemic alterations of regional brain blood flow and energy metabolism had been previously characterized. Pentobarbital-anesthetized cats received either 15 or 30 minutes of ischemia produced by basilar artery and bilateral carotid artery occlusions plus mild hypotension; this was followed by 60 to 90 minutes of normotensive recirculation. The brains were perfusion-fixed for light microscopy. Both insult durations resulted in unequivocal ischemic cell change affecting neurons of the cerebral neocortex, striatum, thalamus, and hippocampus and portions of the rostral brainstem. Animals with 30 minutes of prior ischemia differed from those with 15 minutes ischemia in showing a more apparent regional accentuation of ischemic change in the parasagittal cortical gyri, the sites of previously documented focal postischemic heterogeneities of blood flow and metabolism. In other respects, however, the overall distribution and spectrum of severity of the ischemic alterations were similar for the two insult durations. These data support the view that significant permanent neuronal injury may result from a period of cerebral ischemia as brief as 15 minutes.

Original languageEnglish
Pages (from-to)350-358
Number of pages9
JournalAnnals of Neurology
Volume5
Issue number4
StatePublished - Jan 1 1979
Externally publishedYes

Fingerprint

Brain Ischemia
Cats
Ischemia
Vertebrobasilar Insufficiency
Neocortex
Regional Blood Flow
Brain
Pentobarbital
Thalamus
Carotid Arteries
Hypotension
Energy Metabolism
Brain Stem
Microscopy
Hippocampus
Animal Models
Perfusion
Neurons
Light
Wounds and Injuries

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Diffuse cerebral ischemia in the cat : III. Neuropathological sequelae of severe ischemia. / Ginsberg, Myron; Graham, D. I.; Welsh, F. A.; Budd, W. W.

In: Annals of Neurology, Vol. 5, No. 4, 01.01.1979, p. 350-358.

Research output: Contribution to journalArticle

Ginsberg, Myron ; Graham, D. I. ; Welsh, F. A. ; Budd, W. W. / Diffuse cerebral ischemia in the cat : III. Neuropathological sequelae of severe ischemia. In: Annals of Neurology. 1979 ; Vol. 5, No. 4. pp. 350-358.
@article{8be0f408541f474ab8faa2fc4e8bb13b,
title = "Diffuse cerebral ischemia in the cat: III. Neuropathological sequelae of severe ischemia",
abstract = "The neuropathological consequences of severe diffuse cerebral ischemia were investigated in an animal model in which postischemic alterations of regional brain blood flow and energy metabolism had been previously characterized. Pentobarbital-anesthetized cats received either 15 or 30 minutes of ischemia produced by basilar artery and bilateral carotid artery occlusions plus mild hypotension; this was followed by 60 to 90 minutes of normotensive recirculation. The brains were perfusion-fixed for light microscopy. Both insult durations resulted in unequivocal ischemic cell change affecting neurons of the cerebral neocortex, striatum, thalamus, and hippocampus and portions of the rostral brainstem. Animals with 30 minutes of prior ischemia differed from those with 15 minutes ischemia in showing a more apparent regional accentuation of ischemic change in the parasagittal cortical gyri, the sites of previously documented focal postischemic heterogeneities of blood flow and metabolism. In other respects, however, the overall distribution and spectrum of severity of the ischemic alterations were similar for the two insult durations. These data support the view that significant permanent neuronal injury may result from a period of cerebral ischemia as brief as 15 minutes.",
author = "Myron Ginsberg and Graham, {D. I.} and Welsh, {F. A.} and Budd, {W. W.}",
year = "1979",
month = "1",
day = "1",
language = "English",
volume = "5",
pages = "350--358",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Diffuse cerebral ischemia in the cat

T2 - III. Neuropathological sequelae of severe ischemia

AU - Ginsberg, Myron

AU - Graham, D. I.

AU - Welsh, F. A.

AU - Budd, W. W.

PY - 1979/1/1

Y1 - 1979/1/1

N2 - The neuropathological consequences of severe diffuse cerebral ischemia were investigated in an animal model in which postischemic alterations of regional brain blood flow and energy metabolism had been previously characterized. Pentobarbital-anesthetized cats received either 15 or 30 minutes of ischemia produced by basilar artery and bilateral carotid artery occlusions plus mild hypotension; this was followed by 60 to 90 minutes of normotensive recirculation. The brains were perfusion-fixed for light microscopy. Both insult durations resulted in unequivocal ischemic cell change affecting neurons of the cerebral neocortex, striatum, thalamus, and hippocampus and portions of the rostral brainstem. Animals with 30 minutes of prior ischemia differed from those with 15 minutes ischemia in showing a more apparent regional accentuation of ischemic change in the parasagittal cortical gyri, the sites of previously documented focal postischemic heterogeneities of blood flow and metabolism. In other respects, however, the overall distribution and spectrum of severity of the ischemic alterations were similar for the two insult durations. These data support the view that significant permanent neuronal injury may result from a period of cerebral ischemia as brief as 15 minutes.

AB - The neuropathological consequences of severe diffuse cerebral ischemia were investigated in an animal model in which postischemic alterations of regional brain blood flow and energy metabolism had been previously characterized. Pentobarbital-anesthetized cats received either 15 or 30 minutes of ischemia produced by basilar artery and bilateral carotid artery occlusions plus mild hypotension; this was followed by 60 to 90 minutes of normotensive recirculation. The brains were perfusion-fixed for light microscopy. Both insult durations resulted in unequivocal ischemic cell change affecting neurons of the cerebral neocortex, striatum, thalamus, and hippocampus and portions of the rostral brainstem. Animals with 30 minutes of prior ischemia differed from those with 15 minutes ischemia in showing a more apparent regional accentuation of ischemic change in the parasagittal cortical gyri, the sites of previously documented focal postischemic heterogeneities of blood flow and metabolism. In other respects, however, the overall distribution and spectrum of severity of the ischemic alterations were similar for the two insult durations. These data support the view that significant permanent neuronal injury may result from a period of cerebral ischemia as brief as 15 minutes.

UR - http://www.scopus.com/inward/record.url?scp=0018305255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018305255&partnerID=8YFLogxK

M3 - Article

C2 - 443769

AN - SCOPUS:0018305255

VL - 5

SP - 350

EP - 358

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 4

ER -