Diffuse cerebral ischemia in the cat: II. Regional metabolites during severe ischemia and recirculation

Frank A. Welsh, Myron D. Ginsberg, Wendy Rieder, William W. Budd

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Metabolite levels were measured in 7 brain regions in cats after 15 or 30 min of a severe ischemic insult and after a 90-min period of recirculation following 15 or 30 min of ischemia. Brain levels of phosphocreatine were depleted after a 15- or 30-min insult, and lactate levels were extremely high at both times. The adenosine triphosphate (ATP) content in many brain areas and the presence of microregions of low reduced nicotinamine-adenine dinucleotide in the brains of the animals that had 15 min of ischemia suggested that the ischemia, though severe, was not complete. Recirculation following a 15-min insult restored brain levels of ATP and phosphocreatine to 70 to 100% of control values in all regions analyzed. In contrast, metabolic recovery from a 30-min insult was regionally heterogeneous. Thus, there was persistent depression of ATP and phosphocreatine and elevation of lactate, which was localized in discrete cortical foci near the longitudinal midline. The factors governing the localization of metabolic failure must have been become manifest during the recirculation period since the ischemic insult itself caused similar metabolic perturbations in all cortical regions.

Original languageEnglish (US)
Pages (from-to)493-501
Number of pages9
JournalAnnals of neurology
Volume3
Issue number6
DOIs
StatePublished - Jun 1978
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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