Diffuse astrocytic swelling and increased second messenger activity following acute Haemophilus influenzae meningitis--evidence from a rat model.

W. L. Maxwell, Ross Bullock, A. Scott, Y. Kuroda, D. I. Graham, G. Gallagher

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Despite numerous epidemiological analyses of bacterial meningitis there is very little pathological data concerning the acute glial and neuronal responses to the disease. We have developed a safe, easily used rat model for Haemophilus influenzae type b meningitis. We measured cerebral blood flow, glucose utilisation and second messenger activity in this model, and carried out parallel light and ultrastructural analysis of glial and neuronal responses. Only protein kinase C activity was changed from control values. We obtained evidence for massive astrocytic swelling and neuronal degeneration. We posit that cytotoxic mechanisms may contribute to the pathology of meningitis.

Original languageEnglish
Pages (from-to)45-47
Number of pages3
JournalActa Neurochirurgica, Supplement
Volume60
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

meningitis
Haemophilus Meningitis
influenza
Haemophilus influenzae
Second Messenger Systems
Meningitis
Neuroglia
swelling
rats
Swelling
Rats
Cerebrovascular Circulation
Haemophilus influenzae type b
Bacterial Meningitides
Pathology
Protein Kinase C
Glucose
Blood Glucose
Blood
degeneration

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Diffuse astrocytic swelling and increased second messenger activity following acute Haemophilus influenzae meningitis--evidence from a rat model. / Maxwell, W. L.; Bullock, Ross; Scott, A.; Kuroda, Y.; Graham, D. I.; Gallagher, G.

In: Acta Neurochirurgica, Supplement, Vol. 60, 01.01.1994, p. 45-47.

Research output: Contribution to journalArticle

Maxwell, W. L. ; Bullock, Ross ; Scott, A. ; Kuroda, Y. ; Graham, D. I. ; Gallagher, G. / Diffuse astrocytic swelling and increased second messenger activity following acute Haemophilus influenzae meningitis--evidence from a rat model. In: Acta Neurochirurgica, Supplement. 1994 ; Vol. 60. pp. 45-47.
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