Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques

Leonard A. Rosenblum, E. L P Smith, Margaret Altemus, Bruce A. Scharf, Michael J. Owens, Charles Nemeroff, Jack M. Gorman, Jeremy D. Coplan

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The two neuropeptides corticotropin-releasing-factor (CRF) and oxytocin (OT) may produce opposing behavioral effects - elevations of the former have been associated with anxiety and social vigilance and reductions of the latter with reduced social affiliation. We sought to test the hypothesis that, within the primate macaque genus, the more gregarious, affiliative, and affectively stable bonnet species (Macaca radiata) would exhibit lower cerebrospinal fluid (CSF) CRF and higher CSF OT concentrations in comparison to its close relative, the temperamentally volatile and socially distant pigtail (Macaca nemestrina). Cisternal CSF samples were obtained from young adult male and female pigtail and bonnet macaques, and CRF and OT concentrations were measured by radioimmunoassay. Pigtail macaques exhibited significantly higher concentrations of CSF CRF and significant lower concentrations of CSF OT than bonnet macaques. Results were not attributable to age or sex differences in group composition. When included together in a multiple regression, CRF and OT showed a multiple R of 0.76, accounting for more than half of the species variance. Although species differences in the bioeffectiveness of these peptides may possibly confound the observed biobehavioral relationships, in the absence of any existing data to that effect, the current findings appear in accordance with the hypothesis and consistent with previously reported species-typical behaviors observed in these macaques.

Original languageEnglish
Pages (from-to)651-660
Number of pages10
JournalPsychoneuroendocrinology
Volume27
Issue number6
DOIs
StatePublished - Jun 29 2002
Externally publishedYes

Fingerprint

Macaca radiata
Macaca nemestrina
Corticotropin-Releasing Hormone
Oxytocin
Cerebrospinal Fluid
Macaca
Neuropeptides
Sex Characteristics
Primates
Radioimmunoassay
Young Adult
Anxiety
Peptides

Keywords

  • Behaviour
  • CRF
  • Macaques
  • Oxytocin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems
  • Psychology(all)

Cite this

Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques. / Rosenblum, Leonard A.; Smith, E. L P; Altemus, Margaret; Scharf, Bruce A.; Owens, Michael J.; Nemeroff, Charles; Gorman, Jack M.; Coplan, Jeremy D.

In: Psychoneuroendocrinology, Vol. 27, No. 6, 29.06.2002, p. 651-660.

Research output: Contribution to journalArticle

Rosenblum, Leonard A. ; Smith, E. L P ; Altemus, Margaret ; Scharf, Bruce A. ; Owens, Michael J. ; Nemeroff, Charles ; Gorman, Jack M. ; Coplan, Jeremy D. / Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques. In: Psychoneuroendocrinology. 2002 ; Vol. 27, No. 6. pp. 651-660.
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