Differentiation and tolerance of CD4+ T lymphocytes.

A. K. Abbas, V. L. Perez, L. Van Parijs, R. C. Wong

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The development of effector and memory populations of T lymphocytes is determined by antigen-induced growth and differentiation of naive T cells, and it is regulated by antigen-induced functional tolerance and cell death. CD4+ helper T lymphocytes that vary in their profiles of cytokine production and in effector functions also show distinct responses to antigens and co-stimulatory signals, and they differ in their sensitivity to tolerance induction. Thus, stimuli that trigger T cell growth and differentiation, as well as mechanisms that inhibit T cell expansion, determine both the magnitude and the nature of T cell-dependent immune responses to protein antigens.

Original languageEnglish (US)
Pages (from-to)7-13; discussion 13-19
JournalCiba Foundation symposium
Volume195
StatePublished - 1995

ASJC Scopus subject areas

  • General

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    Abbas, A. K., Perez, V. L., Van Parijs, L., & Wong, R. C. (1995). Differentiation and tolerance of CD4+ T lymphocytes. Ciba Foundation symposium, 195, 7-13; discussion 13-19.