Differentiation and tolerance of CD4+ T lymphocytes.

A. K. Abbas, Victor L Perez Quinones, L. Van Parijs, R. C. Wong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The development of effector and memory populations of T lymphocytes is determined by antigen-induced growth and differentiation of naive T cells, and it is regulated by antigen-induced functional tolerance and cell death. CD4+ helper T lymphocytes that vary in their profiles of cytokine production and in effector functions also show distinct responses to antigens and co-stimulatory signals, and they differ in their sensitivity to tolerance induction. Thus, stimuli that trigger T cell growth and differentiation, as well as mechanisms that inhibit T cell expansion, determine both the magnitude and the nature of T cell-dependent immune responses to protein antigens.

Original languageEnglish
JournalCiba Foundation symposium
Volume195
StatePublished - Dec 1 1995
Externally publishedYes

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T-Lymphocytes
Antigens
Growth
Helper-Inducer T-Lymphocytes
Cell Differentiation
Cell Death
Cytokines
Population
Proteins

ASJC Scopus subject areas

  • General

Cite this

Abbas, A. K., Perez Quinones, V. L., Van Parijs, L., & Wong, R. C. (1995). Differentiation and tolerance of CD4+ T lymphocytes. Ciba Foundation symposium, 195.

Differentiation and tolerance of CD4+ T lymphocytes. / Abbas, A. K.; Perez Quinones, Victor L; Van Parijs, L.; Wong, R. C.

In: Ciba Foundation symposium, Vol. 195, 01.12.1995.

Research output: Contribution to journalArticle

Abbas, AK, Perez Quinones, VL, Van Parijs, L & Wong, RC 1995, 'Differentiation and tolerance of CD4+ T lymphocytes.', Ciba Foundation symposium, vol. 195.
Abbas AK, Perez Quinones VL, Van Parijs L, Wong RC. Differentiation and tolerance of CD4+ T lymphocytes. Ciba Foundation symposium. 1995 Dec 1;195.
Abbas, A. K. ; Perez Quinones, Victor L ; Van Parijs, L. ; Wong, R. C. / Differentiation and tolerance of CD4+ T lymphocytes. In: Ciba Foundation symposium. 1995 ; Vol. 195.
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