Differentiating mild papilledema and buried optic nerve head drusen using spectral domain optical coherence tomography

Kaushal M. Kulkarni, Joshua Pasol, Potyra R. Rosa, Byron L Lam

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Purpose To evaluate the clinical utility of spectral domain optical coherence tomography (SD-OCT) in differentiating mild papilledema from buried optic nerve head drusen (ONHD). Design Comparative case series. Participants Sixteen eyes of 9 patients with ultrasound-proven buried ONHD, 12 eyes of 6 patients with less than or equal to Frisén grade 2 papilledema owing to idiopathic intracranial hypertension. Two normal fellow eyes of patients with buried ONHD were included. Methods A raster scan of the optic nerve and analysis of the retinal nerve fiber layer (RNFL) thickness was performed on each eye using SD-OCT. Eight eyes underwent enhanced depth imaging SD-OCT. Images were assessed qualitatively and quantitatively to identify differentiating features between buried ONHD and papilledema. Five clinicians trained with a tutorial and masked to the underlying diagnosis independently reviewed the SD-OCT images of each eye to determine the diagnosis. Main Outcome Measures Differences in RNFL thickness in each quadrant between the 2 groups and diagnostic accuracy of 5 independent clinicians based on the SD-OCT images alone. Results We found no difference in RNFL thickness between buried ONHD and papilledema in any of the 4 quadrants. Diagnostic accuracy among the readers was low and ranged from 50% to 64%. The kappa coefficient of agreement among the readers was 0.35 (95% confidence interval, 0.19-0.54). Conclusions We found that SD-OCT is not clinically reliable in differentiating buried ONHD and mild papilledema.

Original languageEnglish
Pages (from-to)959-963
Number of pages5
JournalOphthalmology
Volume121
Issue number4
DOIs
StatePublished - Jan 1 2014

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Optic Disk Drusen
Papilledema
Optic Disk
Optical Coherence Tomography
Nerve Fibers
Pseudotumor Cerebri
Optic Nerve
Outcome Assessment (Health Care)
Confidence Intervals

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Differentiating mild papilledema and buried optic nerve head drusen using spectral domain optical coherence tomography. / Kulkarni, Kaushal M.; Pasol, Joshua; Rosa, Potyra R.; Lam, Byron L.

In: Ophthalmology, Vol. 121, No. 4, 01.01.2014, p. 959-963.

Research output: Contribution to journalArticle

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