Differential sensitivity at the cellular level in primary open angle glaucoma: prednisolone and ouabain

Paul Palmberg, D. Rachlin, B. Becker

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The concentration of drug necessary to inhibit lymphocyte transformation by 50 per cent (I50 value) was determined for the glucocorticoid prednisolone 21 phosphate, and for the sodium potassium adenosinetriphosphatase inhibitor ouabain, in 37 persons representing the full range of ocular and cellular glucocorticoid sensitivity. The lymphocytes of patients with primary open angle glaucoma, and of high ocular responders to glucocorticoids, were more sensitive to prednisolone 21 phosphate than were those of ocular low and intermediate responders. By contrast, there was no significant difference in sensitivity to ouabain. There was also no significant correlation of lymphocyte sensitivity to prednisolone 21 phosphate with that to ouabain. These results provide indirect evidence that the increased cellular sensitivity to glucocorticoids in primary open angle glaucoma is a specific effect, and not merely representative of a general vulnerability of 'sick cells'.

Original languageEnglish
Pages (from-to)403-405
Number of pages3
JournalInvestigative Ophthalmology
Volume15
Issue number5
StatePublished - Dec 1 1976
Externally publishedYes

Fingerprint

Ouabain
Prednisolone
Glucocorticoids
Lymphocytes
Lymphocyte Activation
Adenosine Triphosphatases
Potassium
Primary Open Angle Glaucoma
Pharmaceutical Preparations
prednisolone phosphate

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Differential sensitivity at the cellular level in primary open angle glaucoma : prednisolone and ouabain. / Palmberg, Paul; Rachlin, D.; Becker, B.

In: Investigative Ophthalmology, Vol. 15, No. 5, 01.12.1976, p. 403-405.

Research output: Contribution to journalArticle

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