Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma

Charles Nemeroff, Christine M. Heim, Michael E. Thase, Daniel N. Klein, A. John Rush, Alan F. Schatzberg, Philip T. Ninan, James P. McCullough, Paul M. Weiss, David L. Dunner, Barbara O. Rothbaum, Susan Kornstein, Gabor Keitner, Martin B. Keller

Research output: Contribution to journalArticle

513 Citations (Scopus)

Abstract

Major depressive disorder is associated with considerable morbidity, disability, and risk for suicide. Treatments for depression most commonly include antidepressants, psychotherapy, or the combination. Little is known about predictors of treatment response for depression. In this study, 681 patients with chronic forms of major depression were treated with an antidepressant (nefazodone), Cognitive Behavioral Analysis System of Psychotherapy (CBASP), or the combination. Overall, the effects of the antidepressant alone and psychotherapy alone were equal and significantly less effective than combination treatment. Among those with a history of early childhood trauma (loss of parents at an early age, physical or sexual abuse, or neglect), psychotherapy alone was superior to antidepressant monotherapy. Moreover, the combination of psychotherapy and pharmacotherapy was only marginally superior to psychotherapy alone among the childhood abuse cohort. Our results suggest that psychotherapy may be an essential element in the treatment of patients with chronic forms of major depression and a history of childhood trauma.

Original languageEnglish
Pages (from-to)14293-14296
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue numberSUPPL. 2
DOIs
StatePublished - Nov 25 2003
Externally publishedYes

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Psychotherapy
Depression
Drug Therapy
Wounds and Injuries
Antidepressive Agents
Sex Offenses
Major Depressive Disorder
Therapeutics
Suicide
Parents
Morbidity

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. / Nemeroff, Charles; Heim, Christine M.; Thase, Michael E.; Klein, Daniel N.; Rush, A. John; Schatzberg, Alan F.; Ninan, Philip T.; McCullough, James P.; Weiss, Paul M.; Dunner, David L.; Rothbaum, Barbara O.; Kornstein, Susan; Keitner, Gabor; Keller, Martin B.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. SUPPL. 2, 25.11.2003, p. 14293-14296.

Research output: Contribution to journalArticle

Nemeroff, C, Heim, CM, Thase, ME, Klein, DN, Rush, AJ, Schatzberg, AF, Ninan, PT, McCullough, JP, Weiss, PM, Dunner, DL, Rothbaum, BO, Kornstein, S, Keitner, G & Keller, MB 2003, 'Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma', Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. SUPPL. 2, pp. 14293-14296. https://doi.org/10.1073/pnas.2336126100
Nemeroff, Charles ; Heim, Christine M. ; Thase, Michael E. ; Klein, Daniel N. ; Rush, A. John ; Schatzberg, Alan F. ; Ninan, Philip T. ; McCullough, James P. ; Weiss, Paul M. ; Dunner, David L. ; Rothbaum, Barbara O. ; Kornstein, Susan ; Keitner, Gabor ; Keller, Martin B. / Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. In: Proceedings of the National Academy of Sciences of the United States of America. 2003 ; Vol. 100, No. SUPPL. 2. pp. 14293-14296.
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