Differential regulation of the coexpressed calcitonin/α-CGRP and β-CGRP neuroendocrine genes

A. F. Russo, C. Nelson, B. A. Roos, M. G. Rosenfeld

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The rat calcitonin/ξ-CGRP and β-CGRP genes are members of a neuroendocrine gene family that are coexpressed in a distinct cell-specific pattern. The α- and β-CGRP gene sequences predict highly related peptides that differ by only a single amino acid. Using rat medullary thyroid carcinoma cells as an in vitro system for testing hormone responsiveness, we have shown that the calcitonin/α-CGRP and β-CGRP genes are differentially regulated. The synthetic glucocorticoid, dexamethasone, caused a 2- to 5-fold increase in calcitonin and α-CGRP mRNAs due to an incease in the nuclear transcription rate. In contrast, the levels of β-CGRP mRNA did not significantly change following dexamethasone treatment. Differential regulation within neuroendocrine gene families might be a common mechanism for generating functionally similar peptides in response to a variety of hormonal signals.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalJournal of Biological Chemistry
Volume263
Issue number1
StatePublished - Jan 1 1988
Externally publishedYes

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Calcitonin
Genes
Dexamethasone
Rats
Messenger RNA
Peptides
Transcription
Glucocorticoids
Cells
Hormones
Amino Acids
Testing

ASJC Scopus subject areas

  • Biochemistry

Cite this

Differential regulation of the coexpressed calcitonin/α-CGRP and β-CGRP neuroendocrine genes. / Russo, A. F.; Nelson, C.; Roos, B. A.; Rosenfeld, M. G.

In: Journal of Biological Chemistry, Vol. 263, No. 1, 01.01.1988, p. 5-8.

Research output: Contribution to journalArticle

Russo, AF, Nelson, C, Roos, BA & Rosenfeld, MG 1988, 'Differential regulation of the coexpressed calcitonin/α-CGRP and β-CGRP neuroendocrine genes', Journal of Biological Chemistry, vol. 263, no. 1, pp. 5-8.
Russo, A. F. ; Nelson, C. ; Roos, B. A. ; Rosenfeld, M. G. / Differential regulation of the coexpressed calcitonin/α-CGRP and β-CGRP neuroendocrine genes. In: Journal of Biological Chemistry. 1988 ; Vol. 263, No. 1. pp. 5-8.
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