Differential regulation of the coexpressed calcitonin/α-CGRP and β-CGRP neuroendocrine genes

A. F. Russo, C. Nelson, B. A. Roos, M. G. Rosenfeld

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The rat calcitonin/ξ-CGRP and β-CGRP genes are members of a neuroendocrine gene family that are coexpressed in a distinct cell-specific pattern. The α- and β-CGRP gene sequences predict highly related peptides that differ by only a single amino acid. Using rat medullary thyroid carcinoma cells as an in vitro system for testing hormone responsiveness, we have shown that the calcitonin/α-CGRP and β-CGRP genes are differentially regulated. The synthetic glucocorticoid, dexamethasone, caused a 2- to 5-fold increase in calcitonin and α-CGRP mRNAs due to an incease in the nuclear transcription rate. In contrast, the levels of β-CGRP mRNA did not significantly change following dexamethasone treatment. Differential regulation within neuroendocrine gene families might be a common mechanism for generating functionally similar peptides in response to a variety of hormonal signals.

Original languageEnglish (US)
Pages (from-to)5-8
Number of pages4
JournalJournal of Biological Chemistry
Volume263
Issue number1
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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