Differential neurotrophic effects of apolipoprotein E in aged transgenic mice

Isaac Veinbergs, Margaret Mallory, Michael Mante, Edward Rockenstein, John R. Gilbert, Eliezer Masliah

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


The present study seeked to determine whether the neurodegenerative and cognitive alterations in aged apolipoprotein E-deficient mice are differentially reversed by transgenic overexpression of human apolipoprotein- E3 vs. apolipoprotein-E4 in the background of deficient endogenous apolipoprotein E. These studies showed dendritic alterations in pyramidal neurons of apolipoprotein-E4 transgenic mice, similar to the ones observed in apolipoprotein E-deficient mice. However, these mice had a preserved density of synaptophysin-immunoreactive presynaptic terminals. In contrast, mice overexpressing apolipoprotein-E3 showed no synapto-dendritic alterations. Analysis of behavioral performance in the Morris water maze showed that while apolipoprotein E-deficient mice performed poorly, overexpression of apolipoprotein-E3 and, to a lower extent apolipoprotein-E4, resulted in an improved performance. This study supports the contention that, compared with apolipoprotein-E4, apolipoprotein-E3 might have a greater neurotrophic in vivo effect in aged mice.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalNeuroscience Letters
Issue number3
StatePublished - Apr 23 1999


  • Aging
  • Alzheimer's disease
  • Apolipoprotein E
  • Gene knock- out
  • Neurodegeneration
  • Transgenic

ASJC Scopus subject areas

  • Neuroscience(all)


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