Differential neurotrophic effects of apolipoprotein E in aged transgenic mice

Isaac Veinbergs, Margaret Mallory, Michael Mante, Edward Rockenstein, John Gilbert, Eliezer Masliah

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The present study seeked to determine whether the neurodegenerative and cognitive alterations in aged apolipoprotein E-deficient mice are differentially reversed by transgenic overexpression of human apolipoprotein- E3 vs. apolipoprotein-E4 in the background of deficient endogenous apolipoprotein E. These studies showed dendritic alterations in pyramidal neurons of apolipoprotein-E4 transgenic mice, similar to the ones observed in apolipoprotein E-deficient mice. However, these mice had a preserved density of synaptophysin-immunoreactive presynaptic terminals. In contrast, mice overexpressing apolipoprotein-E3 showed no synapto-dendritic alterations. Analysis of behavioral performance in the Morris water maze showed that while apolipoprotein E-deficient mice performed poorly, overexpression of apolipoprotein-E3 and, to a lower extent apolipoprotein-E4, resulted in an improved performance. This study supports the contention that, compared with apolipoprotein-E4, apolipoprotein-E3 might have a greater neurotrophic in vivo effect in aged mice.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalNeuroscience Letters
Volume265
Issue number3
DOIs
StatePublished - Apr 23 1999
Externally publishedYes

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Apolipoproteins E
Apolipoprotein E3
Transgenic Mice
Apolipoprotein E4
Synaptophysin
Pyramidal Cells
Presynaptic Terminals
Water

Keywords

  • Aging
  • Alzheimer's disease
  • Apolipoprotein E
  • Gene knock- out
  • Neurodegeneration
  • Transgenic

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Veinbergs, I., Mallory, M., Mante, M., Rockenstein, E., Gilbert, J., & Masliah, E. (1999). Differential neurotrophic effects of apolipoprotein E in aged transgenic mice. Neuroscience Letters, 265(3), 218-222. https://doi.org/10.1016/S0304-3940(99)00243-8

Differential neurotrophic effects of apolipoprotein E in aged transgenic mice. / Veinbergs, Isaac; Mallory, Margaret; Mante, Michael; Rockenstein, Edward; Gilbert, John; Masliah, Eliezer.

In: Neuroscience Letters, Vol. 265, No. 3, 23.04.1999, p. 218-222.

Research output: Contribution to journalArticle

Veinbergs, I, Mallory, M, Mante, M, Rockenstein, E, Gilbert, J & Masliah, E 1999, 'Differential neurotrophic effects of apolipoprotein E in aged transgenic mice', Neuroscience Letters, vol. 265, no. 3, pp. 218-222. https://doi.org/10.1016/S0304-3940(99)00243-8
Veinbergs I, Mallory M, Mante M, Rockenstein E, Gilbert J, Masliah E. Differential neurotrophic effects of apolipoprotein E in aged transgenic mice. Neuroscience Letters. 1999 Apr 23;265(3):218-222. https://doi.org/10.1016/S0304-3940(99)00243-8
Veinbergs, Isaac ; Mallory, Margaret ; Mante, Michael ; Rockenstein, Edward ; Gilbert, John ; Masliah, Eliezer. / Differential neurotrophic effects of apolipoprotein E in aged transgenic mice. In: Neuroscience Letters. 1999 ; Vol. 265, No. 3. pp. 218-222.
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