Abstract
The comparative effects of chloramphenicol, its nitroso derivative, and thiamphenicol on a number of metabolic parameters in vitro, including DNA and mitochondrial protein synthesis, and the effects of these agents on isolated double-stranded DNA are described. Evidence is presented in support of the hypothesis that the p-nitro group of chloramphenicol is the structural feature underlying aplastic anemia caused by this drug. The capacity of small concentrations of nitroso-chloramphenicol and large concentrations of chloramphenicol to produce breaks in double-stranded DNA suggests that, in the predisposed host, either chloramphenicol or its nitroso derivative may cause DNA damage and mutation, ultimately leading to aplastic anemia and/or leukemia.
Original language | English (US) |
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Pages (from-to) | 340-342 |
Number of pages | 3 |
Journal | Sexually Transmitted Diseases |
Volume | 11 |
DOIs | |
State | Published - Jan 1 1984 |
ASJC Scopus subject areas
- Dermatology
- Public Health, Environmental and Occupational Health
- Microbiology (medical)
- Infectious Diseases