Differential in-vitro toxicity of chloramphenicol, nitroso-chloramphenicol, and thiamphenicol

Adel A. Yunis

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The comparative effects of chloramphenicol, its nitroso derivative, and thiamphenicol on a number of metabolic parameters in vitro, including DNA and mitochondrial protein synthesis, and the effects of these agents on isolated double-stranded DNA are described. Evidence is presented in support of the hypothesis that the p-nitro group of chloramphenicol is the structural feature underlying aplastic anemia caused by this drug. The capacity of small concentrations of nitroso-chloramphenicol and large concentrations of chloramphenicol to produce breaks in double-stranded DNA suggests that, in the predisposed host, either chloramphenicol or its nitroso derivative may cause DNA damage and mutation, ultimately leading to aplastic anemia and/or leukemia.

Original languageEnglish (US)
Pages (from-to)340-342
Number of pages3
JournalSexually Transmitted Diseases
Volume11
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

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