Differential in vitro sensitivity of marrow erythroid and granulocytic colony forming cells to chloramphenicol

Adel A Yunis, J. W. Adamson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effects of chloramphenicol (CAP) and thiamphenicol (TAP) on mouse and human in vitro erythroid (CFU-E) and granulocytic (CFU-C) colony forming units have been studied. Both drugs inhibited CFU-E growth in a concentration-dependent, stereospecific, manner. Complete inhibition of human CFU-E growth was observed at a CAP concentration of 10 μg/ml while a concentration over 50 μg/ml was required to inhibit CFU-C growth. Furthermore, whereas the inhibition of CFU-C growth could be blocked in vitro by high colony stimulating factor concentrations, inhibition of CFU-E growth was not affected by increased erythropoietin (ESF) levels. The lack of protection by ESF may account for the apparent vulnerability of erythroid cells to CAP in vivo.

Original languageEnglish (US)
Pages (from-to)355-363
Number of pages9
JournalAmerican Journal of Hematology
Volume2
Issue number4
StatePublished - 1977

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Chloramphenicol
Erythroid Precursor Cells
Bone Marrow
Growth
Thiamphenicol
Colony-Stimulating Factors
Erythroid Cells
Erythropoietin
Stem Cells
In Vitro Techniques
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Hematology

Cite this

Differential in vitro sensitivity of marrow erythroid and granulocytic colony forming cells to chloramphenicol. / Yunis, Adel A; Adamson, J. W.

In: American Journal of Hematology, Vol. 2, No. 4, 1977, p. 355-363.

Research output: Contribution to journalArticle

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