Differential efficacies of dopamine D1 receptor agonists for stimulating adenylyl cyclase in squirrel monkey and rat

Sari Izenwasser, Jonathan L. Katz

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Adenylyl cyclase activity was stimulated by dopamine to approximately 200% over basal activity in both squirrel monkey caudate and rats caudate-putamen. The selective dopamine D1 receptor agonists SKF 82958, A68930, dihydrexidine, CY 208-243, and SKF 75670 each produced similar maximal stimulation across the two species. SKF 38393, SKF 81297, and 6-Br-APB, however, each had higher efficacy in rat than in monkey. These results suggest differences in dopamine D1 receptors in the two species.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume246
Issue number1
DOIs
StatePublished - Jun 15 1993
Externally publishedYes

Keywords

  • Adenylyl cyclase
  • Dopamine D receptor

ASJC Scopus subject areas

  • Pharmacology

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