Adenylyl cyclase activity was stimulated by dopamine to approximately 200% over basal activity in both squirrel monkey caudate and rats caudate-putamen. The selective dopamine D1 receptor agonists SKF 82958, A68930, dihydrexidine, CY 208-243, and SKF 75670 each produced similar maximal stimulation across the two species. SKF 38393, SKF 81297, and 6-Br-APB, however, each had higher efficacy in rat than in monkey. These results suggest differences in dopamine D1 receptors in the two species.
|Original language||English (US)|
|Number of pages||6|
|Journal||European Journal of Pharmacology: Molecular Pharmacology|
|State||Published - Jun 15 1993|
- Adenylyl cyclase
- Dopamine D receptor
ASJC Scopus subject areas