Differential effects of natural and synthetic vitamin E on gene transcription in murine T lymphocytes

Sung Nim Han, Eunice Pang, Jean Marc Zingg, Simin Nikbin Meydani, Mohsen Meydani, Angelo Azzi

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Mice were supplemented with low and high doses of natural and synthetic vitamin E, T cells from the spleen isolated and stimulated with plate-bound anti-CD3 and soluble anti-CD28, and gene expression changes assessed by gene array experiments. The data obtained indicate significant qualitative and quantitative differences between the two vitamin forms in regulating gene expression in response to T-cell stimulation. Marker genes have been found whose expression can be considered significant in establishing the level of, and response to vitamin E for both natural and synthetic vitamin E supplementation; unique markers for synthetic vitamin E supplementation and unique markers for natural vitamin E supplementation have been identified.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalArchives of Biochemistry and Biophysics
Volume495
Issue number1
DOIs
StatePublished - Mar 2010
Externally publishedYes

Keywords

  • Gene expression
  • RRR-α-tocopherol
  • Synthetic α-tocopherol
  • T-cell

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Differential effects of natural and synthetic vitamin E on gene transcription in murine T lymphocytes'. Together they form a unique fingerprint.

Cite this